Abstract
Asthma is a serious health problem causing significant mortality and morbidity globally. Persistent airway inflammation, airway hyperresponsiveness, increased immunoglobulin E (IgE) levels and mucus hypersecretion are key characteristics of the condition. Asthma is mediated via a dominant T-helper 2 (Th2) immune response, causing enhanced expression of Th2 cytokines. These cytokines are responsible for the various pathological changes associated with allergic asthma. To investigate the anti-asthmatic potential of afzelin, as well as the underlying mechanisms involved, its anti-asthmatic potential were investigated in a murine model of asthma. In the present study, BALB/c mice were systemically sensitized using ovalbumin (OVA) followed by aerosol allergen challenges. The effect of afzelin on airway hyperresponsiveness, eosinophilic infiltration, Th2 cytokine and OVA‑specific IgE production in a mouse model of asthma were investigated. It was found that afzelin‑treated groups suppressed eosinophil infiltration, allergic airway inflammation, airway hyperresponsiveness, OVA-specific IgE and Th2 cytokine secretion. The results of the present study suggested that the therapeutic mechanism by which afzelin effectively treats asthma is...Continue Reading
References
Jul 1, 1995·American Journal of Respiratory Cell and Molecular Biology·A J CoyleG P Anderson
Sep 1, 1994·Trends in Pharmacological Sciences·G P Anderson, A J Coyle
Apr 1, 1993·Molecular and Cellular Biology·R J ArceciD B Wilson
Jul 10, 1996·Developmental Biology·E E MorriseyM S Parmacek
Aug 22, 1997·The Journal of Biological Chemistry·D H ZhangA Ray
Jan 12, 2002·Science·Susanne J SzaboLaurie H Glimcher
Dec 26, 2002·Annual Review of Immunology·Susanne J SzaboLaurie H Glimcher
Apr 15, 2004·Allergy·Matthew MasoliUNKNOWN Global Initiative for Asthma (GINA) Program
Oct 27, 2004·American Journal of Respiratory and Critical Care Medicine·Sang-Heon ChoSebastian L Johnston
Oct 4, 2005·Nature Immunology·Laurie E HarringtonCasey T Weaver
Feb 10, 2006·Cell Research·Jinfang ZhuWilliam E Paul
Feb 24, 2007·International Journal of Pharmaceutics·Olga BorgesAnabela Cordeiro-da-Silva
Aug 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ulaganathan MabalirajanBalaram Ghosh
Sep 2, 2008·Clinical and Experimental Pharmacology & Physiology·Qiang DuKai-Sheng Yin
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philippe PouliotMartin Olivier
Dec 14, 2011·The Journal of Nutrition·Ju-Hyun GongYoung-Hee Kang
Jul 12, 2012·Oncology Letters·Ajeng DiantiniRizky Abdulah
Mar 1, 1989·Journal of Chemical Ecology·C G JonesS J Compton
Citations
Nov 10, 2017·Metallomics : Integrated Biometal Science·Franziska Roth-WalterErika Jensen-Jarolim
Aug 4, 2016·Molecular Medicine Reports·Zhihui WangLihong Ren
Sep 24, 2016·Respiratory Research·Na WangShujuan Jiang
Dec 2, 2015·Oncology Letters·Kai-Chang ZhuJia-Ju Lv
Dec 5, 2020·Domestic Animal Endocrinology·W J WangS Z Wang