AGA Clinical Practice Update on Small Intestinal Bacterial Overgrowth: Expert Review.

Gastroenterology
Eamonn Martin QuigleyMark Pimentel

Abstract

Thanks to ready access to hydrogen breath testing, small intestinal bacterial overgrowth (SIBO) is now commonly diagnosed among individuals presenting with a variety of gastrointestinal and even nongastrointestinal symptoms and is increasingly implicated in lay press and media in the causation of a diverse array of disorders. Its definition, however, remains controversial and true prevalence, accordingly, undefined. The purpose of this review, therefore, was to provide a historical background to the concept of SIBO, critically review current concepts of SIBO (including symptomatology, pathophysiology, clinical consequences, diagnosis and treatment), define unanswered questions and provide a road map toward their resolution. Best Practice Advice statements were developed following discussion by the 3 authors. Two authors each developed text around certain Best Practice Advice based on a review of available literature. All 3 authors reviewed the complete draft and after discussion, redrafting, and further review and revision, all of the authors agreed on a final draft. BEST PRACTICE ADVICE 1: The definition of SIBO as a clinical entity lacks precision and consistency; it is a term generally applied to a clinical disorder where sy...Continue Reading

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Citations

Nov 29, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Kathryn A Chung, Ronald F Pfeiffer
Jan 12, 2021·Digestive Diseases and Sciences·Michael Camilleri, Lawrence A Szarka
Feb 13, 2021·Journal of Clinical Medicine·Casper SkjærbækPer Borghammer
Mar 8, 2021·Best Practice & Research. Clinical Rheumatology·Timothy KanieckiZsuzsanna H McMahan
Mar 30, 2021·Deutsche medizinische Wochenschrift·Gianluca Barbone, Christoph Jochum
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Jul 27, 2021·Gastroenterology Clinics of North America·Edith Pérez de ArceEamonn M M Quigley
Aug 20, 2021·Frontiers in Immunology·Gilda VarricchiGiuseppe Spadaro
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Oct 2, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Katelyn E MadiganRichard B Weinberg
Nov 13, 2021·Expert Review of Gastroenterology & Hepatology·Jinsheng WangXiaohua Hou

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