Agarose hydrogel biomimetic mineralization model for the regeneration of enamel prismlike tissue

ACS Applied Materials & Interfaces
Ying CaoChun Hung Chu

Abstract

Laboratory studies have demonstrated that enamel-like mineralized tissue can be regenerated and used to repair enamel loss. This has implications for the management of noncarious tooth loss resulting from dental erosion, attrition, and abrasion. In this study, we designed a hydrogel biomimetic mineralization model for the regeneration of enamel-like mineralized tissue with a prismatic structure. The mineralized tissue, which was generated by the model on an etched enamel surface in the presence of 500 ppm fluoride, was analyzed with scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and the nanoindentation hardness test. The generated tissue had enamel prismlike layers containing well-defined hexagonal hydroxyapatite crystals. The modulus of elasticity and the nanohardness of the regenerated enamel prismlike tissue were similar to those of natural enamel. Thus, the regeneration of enamel using this hydrogel biomimetic mineralization model is a promising approach for the management of enamel loss.

References

Aug 12, 1999·Journal of Structural Biology·A G FinchamJ P Simmer
Jan 6, 2001·Journal of Dental Research·H B WenA G Fincham
Feb 13, 2001·Archives of Oral Biology·S HabelitzM Balooch
Oct 4, 2002·Biomaterials·Myung Chul Chang, Junzo Tanaka
Sep 16, 2004·Angewandte Chemie·Susanne Busch
Sep 30, 2004·Calcified Tissue International·L Silverman, A L Boskey
Feb 25, 2005·Nature·Kazue YamagishiPisol Senawangse
Jan 9, 2007·Lancet·Robert H SelwitzNigel B Pitts
Nov 11, 2008·Biomaterials·Yuwei FanJanet Moradian-Oldak
May 10, 2011·Journal of Materials Science. Materials in Medicine·Jie WeiShicheng Wei
Sep 29, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Tian-Yun NingQuan-Li Li
Nov 28, 2012·ACS Applied Materials & Interfaces·Yun-Zhi ZhouQuan-Li Li
Jan 23, 2013·Journal of Bioactive and Compatible Polymers·Yuwei FanXiaoming Xu
Apr 11, 2013·Acta Biomaterialia·Qichao RuanJanet Moradian-Oldak
Jul 3, 2013·Journal of Dentistry·Ying CaoChun Hung Chu

❮ Previous
Next ❯

Citations

Mar 5, 2015·International Journal of Molecular Sciences·Chris Ying CaoChun Hung Chu
Aug 8, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qichao Ruan, Janet Moradian-Oldak
Sep 7, 2014·Journal of Dentistry·Ying CaoChun Hung Chu
Feb 24, 2017·Advanced Materials·Shasha YaoRuikang Tang
Sep 8, 2018·Nanoscale·Zhe WangBaiping Fu
Aug 6, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhuoxin ChenJianshu Li
Jan 14, 2020·Advanced Materials·Yan WeiLin Guo
Jul 19, 2017·Biomaterials Science·Chunmei DingJianshu Li
Sep 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kunneng LiangJiyao Li
Nov 2, 2018·F1000Research·Sara El MoshyAmal M El-Motayam
Sep 10, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ziji LingChris Ying Cao
Oct 24, 2020·Bioengineering·Xinchen WuGulden Camci-Unal
Feb 13, 2021·Biomacromolecules·Marco BeaumontAurelien Forget
Feb 4, 2021·Dental Materials : Official Publication of the Academy of Dental Materials·Ke LiCongqin Ning
Jun 19, 2019·Dental Materials : Official Publication of the Academy of Dental Materials·Arndt GuentschBernd W Sigusch
Jul 22, 2021·Materials Today. Bio·X DengA Mata

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.