Agarwood Alcohol Extract Ameliorates Isoproterenol-Induced Myocardial Ischemia by Inhibiting Oxidation and Apoptosis

Cardiology Research and Practice
Canhong WangJianhe Wei

Abstract

Agarwood is a traditional medicine used for treating some diseases, including painful and ischemic diseases. This study was carried out to investigate the potential cardioprotective effect of the whole-tree agarwood-inducing technique-produced agarwood alcohol extract (WTAAE) on isoproterenol- (ISO-) induced myocardial ischemia (MI) in rats and explore the underlying molecular mechanisms. Compared to the MI group, WTAAE pretreatment significantly improved ST wave abnormal-elevation, mitigated myocardial histological damage; decreased creatinine kinase (CK), lactate dehydrogenase (LDH), alanine transaminase (ALT), and aspartate transaminase (AST) levels; reduced hydrogen peroxide (H2O2) and lipid peroxide (LPO) production; and increased total antioxidant capacity (T-AOC) and catalase (CAT) activities. Moreover, agarwood alcohol extracts (AAEs) markedly enhanced the mRNA levels of Nrf2-ARE pathway, and Bcl-2 reduced the apoptotic Bax family mRNA expressions. In addition, the effect of WTAAE was greater than that of wild agarwood alcohol extract (WAAE) and burning-chisel-drilling agarwood alcohol extract (FBAAE). All of these data indicate that WTAAE exerted the protective effects of MI, and its mechanism was associated with upreg...Continue Reading

References

Jul 11, 2006·International Journal of Cardiology·K KarthikeyanS Niranjali Devaraj
Feb 6, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R AnandanP G Viswanathan Nair
May 14, 2008·Current Pharmaceutical Design·Fatih ArslanGerard Pasterkamp
Aug 12, 2010·Bioscience, Biotechnology, and Biochemistry·Mamoru KakinoHideaki Hara
Apr 13, 2011·World Journal of Gastroenterology : WJG·Wei-Li QiaoChang-Dong Yan
Mar 1, 2012·Seminars in Cardiothoracic and Vascular Anesthesia·Anja FrankTobias Eckle
Mar 9, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yangyang LiuHongjiang Chen
Sep 12, 2013·Redox Biology·Emilia KansanenAnna-Liisa Levonen
Jan 5, 2014·Toxicological Research·Sang Il Gum, Min Kyung Cho
Aug 26, 2015·Fitoterapia·Hui-Xia HuoJun Li
Sep 19, 2015·Current Oncology Reports·Ysabella Z A Van SebilleDorothy M Keefe
Apr 12, 2016·Biochemical and Biophysical Research Communications·Yingli MoSaizhu Wu
Jun 28, 2016·Journal of Ethnopharmacology·Yumi Zuhanis Has-Yun HashimHamzah Mohd Salleh
Mar 23, 2015·Toxicology Reports·Paulo Henrique Marcelino de ÁvilaMarize Campos Valadares

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Methods Mentioned

BETA
light microscopy
PCR
biopsies

Software Mentioned

SPSS17

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