PMID: 11908994Mar 23, 2002Paper

Agastinol and agastenol, novel lignans from Agastache rugosa and their evaluation in an apoptosis inhibition assay

Journal of Natural Products
Choonghwan LeeYunghee Kho

Abstract

Investigation of the whole plant of Agastache rugosa resulted in the isolation of two new lignan compounds. Their structures were elucidated as (8S,7'R,8'S)-4-hydroxybenzoic acid 4-(4-hydroxy-3-methoxybenzyl)-2-(4-hydroxy-3-methoxyphenyl)tetrahydrofuran-3-ylmethyl ester (agastinol, 1) and (7'R,8'S)-4-hydroxybenzoic acid 4-(hydroxy-3-methoxybenzylidene)-2-(4-hydroxy-3-methoxyphenyl)-tetrahydrofuran-3-ylmethyl ester (agastenol, 2). Agastinol and agastenol inhibited etoposide-induced apoptosis in U937 cells with IC50 values of 15.2 and 11.4 microg/mL, respectively.

References

Apr 2, 1999·Trends in Pharmacological Sciences·R A KinlochI Hajimohamadreza
Oct 26, 2000·Nature·M O Hengartner

❮ Previous
Next ❯

Citations

May 29, 2012·Journal of Agricultural and Food Chemistry·Pham Anh TuanSang Un Park
Nov 29, 2005·Natural Product Reports·Muhammad SaleemYong Sup Lee
Jun 6, 2014·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Sylwia Zielińska, Adam Matkowski
Jun 23, 2015·Biomedical Chromatography : BMC·Kebede Taye DestaSung Chul Shin
Jun 22, 2017·International Journal of Biological Macromolecules·Hyun Woo LeeHoon Kim
Jan 30, 2019·Natural Product Research·Hui ZhengRong-Tao Li
Feb 9, 2017·BMC Complementary and Alternative Medicine·Pengran CaoWen-Yi Kang
Nov 5, 2014·Chemical & Pharmaceutical Bulletin·Ki Hyun KimKang Ro Lee
Apr 16, 2021·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Hyeon Ji YeoSang Un Park

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis