Agavins reverse the metabolic disorders in overweight mice through the increment of short chain fatty acids and hormones

Food & Function
Alicia Huazano-García, Mercedes G López

Abstract

In this study, the effects of agavins (branched fructans) along with a diet shift on metabolic parameters, short chain fatty acid (SCFA) production and gastrointestinal hormones in overweight mice were established. Male C57BL/6 mice were fed with a standard (ST) or high fat (HF) diet over the course of 5 weeks, with the objective to induce overweightness in the animals, followed by a diet shift (HF_ST) and a diet shift with agavins (HF_ST + A) or inulin (HF_ST + O) for 5 additional weeks. After the first 5 weeks, the HF group showed a 30% body weight gain and an increase in glucose, triglyceride and cholesterol concentrations of 9%, 79% and 38% respectively when compared to the ST group (P < 0.05). Only the overweight mice that received agavins or inulin in their diets reversed the metabolic disorders induced by consumption of the HF diet, reaching the values very close to those of the ST group (P < 0.05). Furthermore, the consumption of agavins or inulin led to higher SCFA concentrations in the gut and modulated hormones such as GLP-1 and leptin involved in food intake regulation (P < 0.05). These findings demonstrate that a change of diet and fructan consumption such as agavins is a good alternative to increase weight loss an...Continue Reading

References

Jun 1, 1995·The Journal of Nutrition·G R Gibson, M B Roberfroid
May 2, 2002·The Journal of Nutrition·Catherine DaubioulNathalie Delzenne
Nov 29, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S Rössner
Dec 24, 2003·Journal of Agricultural and Food Chemistry·Mercedes G LopezGuillermo Mendoza-Diaz
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Mar 11, 2005·Diabetes/metabolism Research and Reviews·Juris J Meier, Michael A Nauck
Mar 7, 2006·Cell Metabolism·Daniel J Drucker
Sep 28, 2006·Journal of Agricultural and Food Chemistry·N Alejandra Mancilla-Margalli, Mercedes G López
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Aug 23, 2007·The British Journal of Nutrition·Judith E Urías-SilvasNathalie M Delzenne
Oct 17, 2007·Annual Review of Physiology·Owais B ChaudhriStephen R Bloom
Apr 29, 2009·Environmental Microbiology·Sylvia H DuncanHarry J Flint
May 16, 2009·Current Pharmaceutical Design·Patrice D Cani, Nathalie M Delzenne
Oct 18, 2012·Journal of Agricultural and Food Chemistry·Erika Mellado-Mojica, Mercedes G López
Feb 13, 2013·The British Journal of Nutrition·Nathalie M DelzennePatrice D Cani
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Amandine EverardPatrice D Cani
Sep 14, 2013·The ISME Journal·Hannelore DanielThomas Clavel

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Citations

Aug 5, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elena Franco-Robles, Mercedes G López
Dec 10, 2016·Journal of Agricultural and Food Chemistry·Chuhan FuZhengquan Su
May 16, 2019·Journal of Experimental Botany·Sarah C DavisAlberto Búrquez
Jun 7, 2017·Applied Biochemistry and Biotechnology·Alicia Huazano-García, Mercedes G López
May 27, 2020·ACS Omega·Evelyn Regalado-RenteríaBertha Irene Juárez-Flores

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