PMID: 2500075Mar 1, 1989Paper

Age- and diabetes-accelerated glycation in the human aorta

Archives of Gerontology and Geriatrics
M OimomiS Maeda

Abstract

The extent of glycation in pieces of human aorta was estimated by determining the content of furosine, which is derived from fructose-lysine through acid hydrolysis. Glycation of human aorta was found to increase with advancing age. A significant positive correlation was found between the degree of atherosclerosis and the furosine level in the aorta in subjects over 60 years of age. Furthermore, the furosine level in the aortae of diabetic patients was significantly higher than that in normal subjects of the same age. These results suggest not only that glycation in the aorta may increase with aging and with the development of arteriosclerosis, but also that diabetes may be related as well to premature aging as to arteriosclerosis.

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Citations

Apr 16, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·K NakashimaY Andoh
Mar 13, 2009·Expert Reviews in Molecular Medicine·Shi Fang YanAnn Marie Schmidt
Jul 21, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Fei Song, Ann Marie Schmidt
Mar 26, 2013·Metabolism: Clinical and Experimental·Prabhakaran KumarNarkunaraja Shanmugam
Jan 24, 2003·Diabetes·Eiji KimotoYoshiki Nishizawa
Jul 14, 2006·Journal of the American Society of Nephrology : JASN·Eiji KimotoYoshiki Nishizawa
Aug 3, 2018·International Journal of Legal Medicine·Aurora ValenzuelaBelén García-Villanova
Sep 20, 2011·Clinical Chemistry·Claudia CangemiLars Melholt Rasmussen

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