Age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 concentrations on the Immulite 2500: results of the Study of Health in Pomerania (SHIP)

Clinical Chemistry and Laboratory Medicine : CCLM
Nele FriedrichHenri Wallaschofski

Abstract

The objective of the present study was to calculate age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) concentrations using quantile regression. From the Study of Health in Pomerania (SHIP), 1798 men and women aged 25-85 years were recruited. Serum IGF-I and IGFBP-3 concentrations were determined using a chemiluminescent immunometric assay on an Immulite 2500 analyzer. Quantile regressions were performed to calculate the 2.5th and 97.5th percentiles. The reference ranges identified 43 (4.6%) women and 41 (4.8%) men with serum IGF-I concentrations, and 47 (5.0%) women and 42 (5.0%) men with serum IGFBP-3 concentrations outside the reference range. The use of quantile regression results in accurate calculation of age- and gender-specific reference ranges for serum IGF-I and IGFBP-3.

References

Oct 29, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Michael Bernd RankeMartin W Elmlinger
Jul 21, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Martin W ElmlingerMichael B Ranke
Dec 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Chatarina LöfqvistKerstin Albertsson Wikland
Aug 17, 2005·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Elijah O KehindeMathew P Abraham
Nov 16, 2005·Hormone Research·Jens O L JørgensenJens Sandahl Christiansen
Nov 13, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Nele FriedrichHenri Wallaschofski

❮ Previous
Next ❯

Citations

Jan 19, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Berrak GuvenSerefden Acіkgoz
Feb 11, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·C SieversH J Grabe
Mar 3, 2017·Medicine and Science in Sports and Exercise·Takudzwa A MadzimaLynn B Panton
Sep 10, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Erika Arseneau, Cynthia M Balion

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Endocrinology
Harald Jörn SchneiderHenri Wallaschofski
Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
Anders Juul
© 2022 Meta ULC. All rights reserved