Age- and race-dependence of the fibroglandular breast density analyzed on 3D MRI.

Medical Physics
Ke NieJeon-Hor Chen

Abstract

The purpose of this study was to evaluate the age- and race-dependence of the breast fibroglandular tissue density based on three-dimensional breast MRI. The normal breasts of 321 consecutive patients including Caucasians, Asians, and Hispanics were studied. The subjects were separated into three age groups: Younger than 45, between 45 and 55, and older than 55. Computer algorithms based on body landmarks were used to segment the breast, and fuzzy c-means algorithm was used to segment the fibroglandular tissue. Linear regression analysis was applied to compare mean differences among different age groups and race/ethnicity groups. The obtained parameters were not normally distributed, and the transformed data, natural log (ln) for the fibroglandular tissue volume, and the square root for the percent density were used for statistical analysis. On the average, the transformed fibroglandular tissue volume and percent density decreased significantly with age. Racial differences in mean transformed percent density were found among women older than 45, but not among women younger than 45. Mean percent density was higher in Asians compared to Caucasians and Hispanics; the difference remained significant after adjustment for age, but no...Continue Reading

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Citations

Mar 8, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Celine M VachonJames N Ingle
Dec 23, 2015·Translational Oncology·Jeon-Hor ChenMin-Ying Su
Dec 4, 2015·Medical Physics·Kwan-Hoong Ng, Susie Lau
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May 17, 2015·Medical Physics·Jeon-Hor ChenMin-Ying Su
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May 12, 2021·Cellular and Molecular Life Sciences : CMLS·Biyao YangWei Deng
Aug 31, 2021·Journal of Psychosocial Oncology Research and Practice·Jami FukuiIan Pagano

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