Age- and sex-dependent alteration of functions and epigenetic modifications of vessel and endothelium related biomarkers

Turkish Journal of Biology = Türk Biyoloji Dergisi
Sevtap HanEmine Demirel Yilmaz

Abstract

Aging is a main risk factor for development of cardiovascular diseases associated with the impairment of endothelial function in both sexes. In the present study, age-related changes in vascular responsiveness, epigenetic modifications of vessel wall, and blood biomarkers related to endothelial functions were examined in an age- and sex-dependent manner. Acetylcholine (ACh)-induced relaxations of the aorta were decreased in 3-, 6-, and 12-month-old rats compared to those in 1-month-old female rats. In males, maximum relaxations related to ACh were higher in 1- and 6-month-old rats than in 3- and 12-month-old rats. Plasma levels of nitric oxide (NO) and asymmetric dimethylarginine (ADMA) decreased with age in female rats, and total antioxidant capacity (TAC) and hydrogen sulfide (H 2S) levels displayed biphasic alterations. In male rats, plasma levels of NO, TAC, and ADMA decreased with age, and H2S levels increased. Aging also caused a sex-dependent alteration in epigenetic modification of vessels. Expressions of H3K27me2, H3K27me3, H3K36me2, and H3K36me3 were much higher in vessels of 12-month-old female rats compared to those in younger age groups. These results indicate that vascular functions, epigenetic modifications of ve...Continue Reading

Citations

Aug 9, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Joanne F GarbinciusDaniel E Michele
Jul 3, 2021·Jornal Vascular Brasileiro·Adenauer Marinho de Oliveira GóesWaldonio de Brito Vieira

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