Age- and sex-dependent expression of multiple murine hepatic hydroxysteroid sulfotransferase (SULT2A) genes.

Biochemical Pharmacology
T A KocarekM A Runge-Morris

Abstract

Hydroxysteroid sulfotransferase (SULT2A) enzymes play important roles in hepatic steroid and xenobiotic metabolism. Unlike humans, which express one SULT2A, inspection of mouse genome information indicated the presence of seven SULT2A genes within a cluster on chromosome 7. The age- and sex-dependent expressions of the seven murine SULT2A family members were characterized in the livers of C57BL/6 mice using real-time RT-PCR. The transcripts for three of the SULT2A forms (NCBI reference/model sequences XM_001471624, NM_009286 and NM_001111296) were abundant in pre-pubertal male and female mouse liver but were essentially silenced in the livers of adult male mice. The mRNAs of three other SULT2A forms (NM_001101534, XM_894052 and NM_001081325) were also expressed in pre-pubertal male and female mouse liver, but at markedly reduced levels relative to those of the abundant forms. The mRNA levels of these lower-abundance forms were further suppressed in adult animals. A seventh SULT2A mRNA (XM_983034) was expressed in adult male and female mouse liver, but was not detected in pre-pubertal mouse liver of either sex. Full-length amplifications with primers targeting untranslated regions confirmed that all SULT2A forms were expressed. ...Continue Reading

References

Jul 1, 1991·Trends in Pharmacological Sciences·C N Falany
Jan 1, 1993·The Biochemical Journal·K A ComerC N Falany
Jun 1, 1994·Chemico-biological Interactions·A N Kong, P Fei
Mar 1, 1994·Toxicology and Applied Pharmacology·M Runge-Morris, J Wilusz
Sep 5, 2001·The Journal of Biological Chemistry·C S SongB Chatterjee
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Junichiro SonodaRonald M Evans
Dec 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert L StrausbergUNKNOWN Mammalian Gene Collection Program Team
Mar 15, 2003·The Journal of Biological Chemistry·Hirotaka KitadaYasushi Yamazoe
Feb 24, 2004·Molecular Pharmacology·Ibtissam EchchgaddaBandana Chatterjee
Nov 16, 2004·Mechanisms of Ageing and Development·Ibtissam EchchgaddaBandana Chatterjee
Jun 30, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yazen Alnouti, Curtis D Klaassen
Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hirdesh UppalWen Xie
Apr 12, 2007·PLoS Biology·Abdellah Allali-HassaniCheryl H Arrowsmith

❮ Previous
Next ❯

Citations

Jun 2, 2009·Molecular Pharmacology·David J Waxman, Minita G Holloway
Sep 12, 2013·Drug Metabolism Reviews·Charles N Falany, Katie Jo Rohn-Glowacki
Jan 22, 2013·Drug Metabolism Reviews·Melissa Runge-MorrisCharles N Falany
Mar 15, 2015·Biopharmaceutics & Drug Disposition·Chunming LyuZhong Zuo
May 14, 2016·Chemico-biological Interactions·Michael W H Coughtrie
Apr 25, 2018·Bioscience, Biotechnology, and Biochemistry·Takehiko ShimohiraYoichi Sakakibara
May 19, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Mayur K LadumorBhagwat Prasad
Jul 17, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Cexiong FuHui Zhang
May 16, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kathleen G BarrettMelissa Runge-Morris
Oct 19, 2017·Scientific Reports·Salma E Jiménez-BadilloJavier Hernández-Sánchez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.