Age- and sex-related differences in myosin heavy chain isoforms and muscle strength, function, and quality: a cross sectional study

Journal of Exercise Nutrition & Biochemistry
Seung-Lyul OhJae-Young Lim

Abstract

Declining muscle strength and function are hallmarks of the aging process. This study aimed to determine sex-related differences in myosin heavy chain (MHC) isoforms and muscle mass, strength, and quality with aging. This cross-sectional study recruited 53 healthy participants (32 men, 21 women) aged 20-85 years who were divided into four groups: young men (n=17, YM, 29.23±4.51), older men (n=15, OM, 71.87±3.42), young women (n=11, YW, 29.64±4.88), and older women (n=10, OW, 68.1±1.91). Body composition and muscle strength and quality were analyzed. Muscle specimens were obtained from the vastus lateralis in all participants to analyze the type of MHC isoforms. Men showed a greater age-related decline in skeletal muscle mass (18.6%, p<0.01), lean body mass (10.1%, p<0.05), grip strength (35.3%, p<0.001), isometric strength (29.6%, p<0.001), isotonic power (42.5%, p<0.001), isokinetic strength (up to 44.3%, p<0.001), and muscle quality (up to 24.8%, p<0.01). In contrast, women had significantly lower isometric strength (24.2%, p<0.05), isotonic power (36.5%, p<0.01), and upper-body muscle quality (24.7%, p<0.001) with aging. In addition, the proportion of MHC IIa was significantly lower in OM (p<0.05) and OW (p<0.05) than in YM ...Continue Reading

References

Feb 1, 1992·Journal of the Neurological Sciences·J Lexell, D Downham
Jun 1, 1997·The American Journal of Physiology·J L Andersen, S Schiaffino
Jan 7, 1998·Journal of Applied Physiology·R S LindleB F Hurley
Aug 26, 1998·Medicine and Science in Sports and Exercise·P Aagaard, J L Andersen
Feb 1, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jeffrey J WidrickChristine M Snow
Feb 18, 2003·Journal of the American Geriatrics Society·Anne B NewmanUNKNOWN Health Aging And Body Composition Research Group
Jul 3, 2003·The Journal of Physiology·Scott TrappeTodd Trappe
Sep 13, 2003·Journal of Applied Physiology·Timothy J Doherty
Oct 17, 2003·The Journal of Physiology·Giuseppe D'AntonaRoberto Bottinelli
Apr 6, 2004·The Journal of Physiology·Scott TrappePer Tesch
Apr 15, 2006·Journal of Applied Physiology·Scott TrappeDavid Whitsett
May 2, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dustin SlivkaScott Trappe
Jun 11, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Adam R KonopkaMatthew P Harber
Sep 2, 2011·Clinical Orthopaedics and Related Research·Stefan GanteliusEva Pontén
Mar 20, 2012·Archives of Gerontology and Geriatrics·R Pedrero-ChamizoUNKNOWN EXERNET Study Group
Apr 6, 2012·Journal of Cachexia, Sarcopenia and Muscle·Kristina NormanMatthias Pirlich
Jun 1, 2013·Clinical Interventions in Aging·Zoran MilanovićNic James
Apr 2, 2016·Journal of Aging Research·Cassandra M GermainDouglas R McQuoid
Dec 5, 2016·Journal of the American Medical Directors Association·Francesco LandiEmanuele Marzetti

❮ Previous
Next ❯

Citations

Jan 5, 2021·Annals of Geriatric Medicine and Research·Hyo-Seong YeoNa-Young Ahn
Jan 17, 2021·International Journal of Environmental Research and Public Health·David Mancha-TrigueroSergio J Ibáñez

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
X-ray
electrophoresis

Software Mentioned

SPSS
ImageJ

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.