Age- and sex-specific reference intervals for hematologic analytes in Chinese children

International Journal of Laboratory Hematology
Xiaoan ZhangEnwu Yuan

Abstract

Reference intervals for pediatric laboratory tests need to be interpreted in the context of age- and sex-dependent dynamics. However, few reference intervals for healthy ethnic Han Chinese children have previously attempted to establish using large sample sizes. As such, there are no national hematological standards in China for pediatric reference intervals. We used a direct method to enroll a total of 2164 healthy 1- to 7-year-old children from Henan province. Hematological reference intervals were established by analyzing venous blood sample data on 17 hematologic analytes. The reference values for different ages and sexes were estimated using both parametric methods (mean ± 2 SD) and nonparametric methods (2.5-97.5th percentiles). We provided reference intervals for 17 hematologic analytes including red blood count, hemoglobin concentration, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and red cell distribution width, white blood count and differential count as well as platelet count and related parameters. We established age- and sex-specific reference intervals that can provide more evidence-based guidance for the diagnosis and treatment for pediatric disease...Continue Reading

References

Jan 1, 1991·Acta Paediatrica Scandinavica. Supplement·G H Pelto
Mar 1, 1984·The American Journal of Clinical Nutrition·R YipP R Dallman
Mar 1, 1997·Clinical and Laboratory Haematology·M R TaylorJ R O'Donnell
Jun 30, 2004·Scandinavian Journal of Clinical and Laboratory Investigation·P RustadA Uldall
Mar 24, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tonya KratovilEdward C C Wong
Sep 4, 2008·Ophthalmic Genetics·Robert K Koenekoop
Jul 9, 2011·Advances in Pediatrics·Vincent A Fulginiti
Nov 1, 2011·Clinical Biochemistry·Tim Lang
Mar 2, 2012·Clinical Chemistry·Ferruccio Ceriotti
Mar 22, 2012·Endocrinology·Sabra L Klein
Mar 2, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Mattias AldrimerDan Hellberg
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·David FurmanMark M Davis
Feb 21, 2018·Hematology/oncology Clinics of North America·Vip Viprakasit, Supachai Ekwattanakit

❮ Previous
Next ❯

Citations

Jun 15, 2020·Current Environmental Health Reports·Lauren M PetrickMegan M Niedzwiecki
Aug 18, 2020·BioMed Research International·Abdoul Habib BéavoguiAbdoulaye Djimdé
Feb 16, 2021·International Journal of Laboratory Hematology·Akiyoshi TakamiUNKNOWN Japanese Society for Laboratory Hematology subcommittee on Standardization of Blood Cell Morphology (JSLH-SBCM)
Jun 4, 2021·International Journal of Hematology·Akiyoshi TakamiUNKNOWN Japanese Society for Laboratory Hematology Standardization Committee (JSLH-SC) and Joint Working Group of the JSLH and the J
Jun 15, 2021·International Journal of Laboratory Hematology·Si ChenHong Jiang
Jun 30, 2021·International Journal of Laboratory Hematology·MeiYan SongLiJuan Ma
Jun 22, 2021·Frontiers in Pediatrics·Yunjia TangHaitao Lv

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.