PMID: 8970217Dec 1, 1996Paper

Age- and time-related changes in extracellular viral load in children vertically infected by human immunodeficiency virus

The Pediatric Infectious Disease Journal
K McIntoshS K Burchett

Abstract

It is known that plasma or serum viral load is high in vertically HIV-infected children during the first year of life, but the changes in these titers after the first birthday have not been described. Information on the natural history of circulating extracellular virus will be useful in elucidating the pathogenesis of pediatric HIV infection and in using viral load measurement to guide prognosis and therapy. We measured serum RNA by reverse transcriptase-polymerase chain reaction and immune complex-dissociated p24 antigen enzyme-linked immunosorbent assay over time in 48 unselected children followed in our clinics and analyzed the findings in relation to age and clinical outcome. In first-available samples from the 48 children there was a gradual reduction in HIV RNA values with increasing age, with a slope of -0.21 log copy/ml/year (P < 0.001, R2 = 0.6022). This downward trend was seen in subsets of children with all degrees of immunodeficiency. The mean slope of repeated HIV RNA measurements in individual children was similarly in a downward direction (slope -0.11 (P = 0.007 for difference from zero)). The slope was more negative in children who were younger at baseline. Immune complex-dissociated p24 antigen values were muc...Continue Reading

References

Mar 1, 1979·The American Journal of Clinical Nutrition·P V HamillW M Moore
Mar 1, 1990·Journal of Clinical Microbiology·R BoomJ van der Noordaa
Jul 23, 1987·Nature·B D WalkerR T Schooley
Apr 15, 1995·Annals of Internal Medicine·J W MellorsP Gupta
Jan 15, 1996·The Journal of Clinical Investigation·A De RossiL Chieco-Bianchi

❮ Previous
Next ❯

Citations

Sep 13, 2002·Journal of Medical Virology·Jane MullenPhilippa Easterbrook
Mar 7, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul KrogstadUNKNOWN Pediatric AIDS Clinical Trials Group 377 Study Team
Jan 18, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kunjal PatelUNKNOWN Pediatric AIDS Clinical Trials Group 219/219C Study Team
Apr 23, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kunjal PatelUNKNOWN Pediatric AIDS Clinical Trials Group 219/219C Study Team
May 20, 1998·AIDS Research and Human Retroviruses·S TetaliS G Pahwa
Dec 1, 2009·AIDS Research and Human Retroviruses·Elizabeth CavalieriLuiz Mario Janini
Apr 12, 2011·AIDS Research and Human Retroviruses·Bongeka NqokoWillem A Hanekom
May 10, 2001·Clinical Obstetrics and Gynecology·M Khoury, A Kovacs
Feb 13, 2002·The Pediatric Infectious Disease Journal·Ram YogevUNKNOWN Pediatrics AIDS Clinical Trials Group 338 Study Team
Jun 24, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·D E KirschnerA S Perelson
Nov 20, 1998·Acta Paediatrica Japonica; Overseas Edition·M TogawaR Murata
May 18, 1999·Archives of Disease in Childhood·Y S BoriskinJ C Booth
Aug 15, 2002·Paediatric Drugs·Patrick J Gavin, Ram Yogev
Jan 7, 2014·Current HIV/AIDS Reports·Nicole H Tobin, Grace M Aldrovandi
Jan 16, 2016·Annual Review of Medicine·Katherine Luzuriaga
Aug 10, 2005·The British Journal of Dermatology·E Seoane ReulaM A Muñoz-Fernandez
Jun 19, 2013·Immunological Reviews·Nicole H Tobin, Grace M Aldrovandi
Mar 4, 2000·Pediatric Clinics of North America·K Luzuriaga, J L Sullivan
Jan 16, 1998·Obstetrics and Gynecology Clinics of North America·A J Melvin, L M Frenkel
Jun 13, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marta Martínez-BonetJavier Martinez-Picado
Jan 30, 2007·Expert Opinion on Pharmacotherapy·Takehisa IkedaJames M Oleske
Nov 20, 2009·Scandinavian Journal of Infectious Diseases·Filip JosephsonUNKNOWN Swedish Reference Group for Antiviral Therapy
Aug 28, 2007·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Elcio LealRicardo S Diaz
May 27, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Gerardo C PalaciosMark Holodniy
Jul 22, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·P KrogstadA Garfinkel
Apr 14, 2004·Neonatal Network : NN·Givens Susan Bell
Nov 3, 2016·Infectious Diseases·Jaran EriksenAnders Sönnerborg
Jan 8, 2016·PLoS Computational Biology·Jayna RaghwaniOliver G Pybus
May 24, 2014·The Cochrane Database of Systematic Reviews·Martina PenazzatoElaine Abrams
Aug 25, 2012·Nature Reviews. Immunology·Andrew J PrendergastPhilip J R Goulder
Dec 19, 2015·Current Opinion in HIV and AIDS·Julia M RoiderPhilip J R Goulder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.