Age, abdominal obesity, and glycated hemoglobin are associated with carotid atherosclerosis in type 2 diabetes patients with nonalcoholic fatty liver disease

Medical Ultrasonography
Cristina Alina SilaghiCarmen Emanuela Georgescu

Abstract

The aim of this study was to evaluate the impact of clinical parameters and indices of body composition on the relation between non-alcoholic fatty liver disease (NAFLD) and carotid intima-media thickness (cIMT), in a type 2 diabetes mellitus population (T2DM). We retrospectively enrolled 336 T2DM outpatients who regularly attended Regina Maria Clinic in Cluj. Clinical, anthropometric and biochemical parameters were measured. Ultrasonography (US) was used to assess hepatic steatosis (HS) in all patients and cIMT in 146 subjects. Body composition was assessed by bioelectric impedance (BIA, InBody 720) in all patients. cIMT was correlated with age (r=0.25; p=0.004), systolic blood pressure (r=0.18; p=0.041), glycated haemoglobin A1C (HbA1C, r=0.20; p=0.04), and with coronary artery disease (r=0.20; p=0.007). HS did not correlate with cIMT (r=0.04; p=0.64). cIMT was correlated with visceral fatty area (VFA, r=0.18; p=0.014) but not with other indices of body composition. Homeostasis model assessment for insulin resistance (HOMA-IR) was not correlated with cIMT (r=0.17; p=0.086). After multivariate analysis, age, HbA1c, and VFA were good independent predictors of cIMT (r=0.45; p < 0.001). These results are suggestive that in T2DM p...Continue Reading

Citations

Aug 22, 2016·Archives of Gerontology and Geriatrics·Małgorzata LipowskaDorota Dykalska-Bieck
Nov 9, 2016·Endocrinology and Metabolism Clinics of North America·Fernando Bril, Kenneth Cusi
Dec 31, 2019·Experimental and Therapeutic Medicine·Tian-Xiao HuJing Wang
May 8, 2019·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Eugene Choon-Li TanSanjiv Mahadeva
Jan 27, 2016·Digestive Diseases and Sciences·Alessandro MantovaniGiovanni Targher
Jan 12, 2021·Canadian Journal of Gastroenterology & Hepatology·Cristina M MuzicaCarol Stanciu
May 19, 2021·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Tiantian SongShuchun Chen

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