Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of Ageing.

Brain : a Journal of Neurology
David DolanRichard J O'Brien

Abstract

Recent studies suggest that dementia in the most elderly (90 years of age and above) is only modestly related to Alzheimer's disease pathology. This raises the possibility that other, as yet unknown, disease processes may underlie dementia in this rapidly growing demographic group, and that efforts designed to combat Alzheimer's disease may not be appropriate for treating dementia in very elderly subjects. To study this question more closely, we examined the relationship between neocortical Alzheimer-type brain pathology and dementia in consecutive autopsies from 209 participants in the Baltimore Longitudinal Study of Ageing, a prospective longitudinal cohort study of the effect of ageing on cognition. Almost half of the cohort was older than 90 years of age at death. We found that several measures of neocortical Alzheimer's pathology, including the Consortium to Establish a Registry of Alzheimer's Disease neuritic plaque score and the Braak neurofibrillary tangle score, remained significant predictors of dementia, independent of age. In participants older than 90 years of age, intracranial atherosclerosis emerged as an important predictor of dementia in subjects with low Alzheimer's pathology scores, but did not mitigate the i...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Aug 2, 1996·The Journal of Biological Chemistry·D J Selkoe
Mar 29, 2000·JAMA : the Journal of the American Medical Association·J NäslundJ D Buxbaum
Nov 16, 2001·Archives of Neurology·G M McKhannUNKNOWN Work Group on Frontotemporal Dementia and Pick's Disease
Aug 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Randy L BucknerMark A Mintun
Oct 21, 2005·Neurology·I G McKeithUNKNOWN Consortium on DLB
Aug 18, 2006·Journal of Alzheimer's Disease : JAD·Kurt A Jellinger
Dec 29, 2006·Annals of Neurology·Ira DriscollAlan B Zonderman
May 23, 2008·Annals of Neurology·Juan C TroncosoRichard J O'Brien
Sep 10, 2008·Archives of Neurology·Vahram HaroutunianHillel T Grossman
May 29, 2009·The New England Journal of Medicine·George M SavvaUNKNOWN Medical Research Council Cognitive Function and Ageing Study
Jul 7, 2009·Brain Research Bulletin·M Hasan Mohajeri, Genevieve Leuba
Jul 28, 2009·Biochimica Et Biophysica Acta·Andreas Kern, Christian Behl
Oct 6, 2009·Lancet·Kaare ChristensenJames W Vaupel
Nov 11, 2009·Archives of Neurology·Christiane ReitzRichard Mayeux

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Citations

Jul 6, 2013·Journal of Neural Transmission·P Martinez-Martin
Jun 5, 2013·Nature Reviews. Neurology·Zixuan YangPerminder S Sachdev
May 21, 2011·Brain : a Journal of Neurology·Peter T NelsonRichard J Kryscio
Nov 29, 2011·Brain : a Journal of Neurology·John L RobinsonJohn Q Trojanowski
Jul 23, 2011·Stroke; a Journal of Cerebral Circulation·Philip B GorelickUNKNOWN American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Counci
Apr 5, 2011·Annual Review of Neuroscience·Richard J O'Brien, Philip C Wong
Nov 25, 2014·Alzheimer's Research & Therapy·Jasmin Rahimi, Gabor G Kovacs
Oct 30, 2016·International Journal of Geriatric Psychiatry·Sarah T McCutcheonJeannie-Marie S Leoutsakos
Jun 5, 2014·Climacteric : the Journal of the International Menopause Society·V W Henderson
Feb 10, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joseph S GoveasMark A Espeland
Nov 26, 2010·Journal of Neuropathology and Experimental Neurology·Lidia SinkaPanteleimon Giannakopoulos
Apr 3, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Heiko Braak, Kelly Del Tredici
Aug 13, 2011·Maturitas·Carrie Brumback-PeltzClaudia H Kawas
Apr 11, 2012·Journal of Neuropathology and Experimental Neurology·Peter T NelsonThomas G Beach
Aug 25, 2010·Journal of Cellular and Molecular Medicine·Kurt A Jellinger
Mar 12, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Daniel J BerlauJohn Q Trojanowski
Aug 6, 2014·Journal of Neural Transmission·Kurt A Jellinger, Johannes Attems
Apr 22, 2011·Neurobiology of Aging·Gregory A JichaPeter T Nelson
Jan 15, 2014·Biochemical Pharmacology·Stephen W ScheffPeter T Nelson
Sep 15, 2011·American Journal of Alzheimer's Disease and Other Dementias·Marcel G M Olde RikkertGunhild Waldemar
Oct 17, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Abhay MoghekarRichard J O'Brien
Oct 30, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jon B ToledoUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 28, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Mitchel A KlingSteven E Arnold
Sep 7, 2018·Experimental and Therapeutic Medicine·Jingru Du, Junfeng Li
Jul 22, 2014·Journal of Internal Medicine·P CermakovaD Religa
Aug 3, 2020·Journal of Neural Transmission·Kurt A Jellinger
Jun 20, 2018·Acta Neuropathologica·John L RobinsonJohn Q Trojanowski

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