Age and body weight effects on glucose and insulin tolerance in colony cats maintained since weaning on high dietary carbohydrate

Journal of Animal Physiology and Animal Nutrition
R C BackusV C Biourge

Abstract

High dietary carbohydrate is suggested to promote development of diabetes mellitus in cats. Glucose tolerance, insulin sensitivity, and insulin secretion were assessed in young [0.8-2.3 (median = 1.1) years, n = 13] and mature [4.0-7.0 (median 5.8) years, n = 12] sexually intact females of a large (n ≅ 700) feline colony in which only dry-type diets (35% metabolizable energy as carbohydrate) were fed from weaning. Insulin sensitivity was assessed from the 'late-phase' (60-120 min) plasma insulin response of intravenous glucose tolerance tests (IVGTTs) and from fractional change in glycaemia from baseline 15 min after an insulin bolus (0.1 U/kg, i.v.). Insulin secretion was assessed from the 'early-phase' (0-15 min) plasma insulin response of IVGTTs. Compared to the young cats, the mature cats had greater body weights [2.3-3.8 (median = 2.9) vs. 3.0-6.3 (median = 4.0) kg, p < 0.01], greater late-phase insulin responses (p < 0.05), lower insulin-induced glycaemic changes (p = 0.06), lower early-phase insulin responses (p < 0.05), and non-significantly different rates of glucose disposal. The late-phase insulin response was correlated with body weight and age (p < 0.05). When group assignments were balanced for body weight, the ag...Continue Reading

References

Jun 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·A AkinmokunK G Alberti
Sep 1, 1990·American Journal of Veterinary Research·R W NelsonG D Bottoms
Dec 1, 1994·Diabetologia·J C Miller, S Colagiuri
Mar 1, 1997·Journal of Veterinary Internal Medicine·V BiourgeQ R Rogers
Jan 30, 2002·Diabetes·Stefano Del PratoRiccardo C Bonadonna
Mar 29, 2002·Journal of Feline Medicine and Surgery·J R FeldhahnG Martin
Apr 20, 2002·European Journal of Clinical Nutrition·S Colagiuri, J Brand Miller
May 25, 2002·Journal of Feline Medicine and Surgery·D J AppletonG D Sunvold
Sep 27, 2002·Journal of Veterinary Internal Medicine·M HoenigD C Ferguson
Nov 15, 2002·Molecular and Cellular Endocrinology·M Hoenig
Dec 14, 2002·Journal of the American Veterinary Medical Association·Debra L Zoran
Apr 6, 2004·Domestic Animal Endocrinology·C L BrennanD C Ferguson
Jun 29, 2006·ILAR Journal·Michael S Henson, Timothy D O'Brien
Aug 12, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M HoenigD C Ferguson
Dec 15, 2006·Nature·Steven E KahnKristina M Utzschneider
May 30, 2007·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·L I SlingerlandA Rijnberk
Apr 9, 2008·European Journal of Internal Medicine·John Kellett

❮ Previous
Next ❯

Citations

Jun 22, 2014·The Veterinary Clinics of North America. Small Animal Practice·Marjorie L Chandler, Gregg Takashima
Jun 19, 2014·Journal of the American Veterinary Medical Association·Tammy J OwensAndrea J Fascetti
Jan 15, 2015·The Journal of Small Animal Practice·L J Davison
Feb 25, 2014·Journal of Feline Medicine and Surgery·Carly Anne Bloom, Jacquie Rand
Jul 10, 2012·Journal of Diabetes Science and Technology·Margarethe Hoenig
Jul 3, 2016·Journal of Feline Medicine and Surgery·Jan BellowsAnna K Shoveller
Sep 24, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Margarethe HoenigDarin E Olson
Oct 7, 2017·Journal of Animal Physiology and Animal Nutrition·S E HooperS Amelon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.