Age‑ and brain region‑associated alterations of cerebral blood flow in early Alzheimer's disease assessed in AβPPSWE/PS1ΔE9 transgenic mice using arterial spin labeling

Molecular Medicine Reports
Yapei GuoHengfang Liu

Abstract

It has been suggested that cerebral blood flow (CBF) alterations may be involved in the pathogenesis of Alzheimer's disease (AD). However, how CBF changes with age has not been detailed in AD, particularly in its early stages. The objective of the present study was to evaluate CBF in four brain regions (the hippocampus, entorhinal cortex, frontoparietal cortex and thalamus) of mice in four age groups, to mimic the respective stages of AD in humans [2 months (pre‑clinical), 3.5 months (sub‑clinical), 5 months (early‑clinical) and 8 months (mid‑clinical)], to understand the age‑associated changes in selected brain regions and to elucidate the underlying vascular mechanisms. CBF was measured using magnetic resonance imaging‑arterial spin labelling (ASL) under identical conditions across the age groups of AβPPSWE/PS1ΔE9 (APP/PS1) transgenic mice with AD. The results indicated age‑ and brain region‑associated changes in CBF were associated with early AD. More precisely, an age‑dependent increase in CBF (in the pre‑ and sub‑clinical AD groups) was observed in the frontoparietal cortex and thalamus. Conversely, increased CBF demonstrated an age‑dependent decline (in the early‑ and mid‑clinical AD groups) in all examined brain regions....Continue Reading

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Citations

Sep 1, 2020·Acta Neuropathologica·Nils KorteDavid Attwell
Jul 3, 2021·Frontiers in Aging Neuroscience·Sanghamitra Bandyopadhyay

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Methods Mentioned

BETA
transgenic

Software Mentioned

ImageJ
ParaVision
GraphPad Prism
GraphPad

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