Age and immunity

Immunity & Ageing : I & a
Sonya VastoGraham Pawelec

Abstract

Longitudinal studies are defining progressive alterations to the immune system associated with increased mortality in the very elderly. Many of these changes are exacerbated by or even caused by chronic T cell stimulation by persistent antigen, particularly from Cytomegalovirus. The composition of T cell subsets, their functional integrity and representation in the repertoire are all markedly influenced by age and by CMV. How these findings relate to epidemiological, functional, genetic, genomic and proteomic studies of human T cell immunosenescence was the subject of intense debate at an international conference held just before Christmas 2005 in the Black Forest.

References

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Citations

Oct 14, 2008·Rejuvenation Research·Carl F FortinTàmàs Fülöp
Dec 1, 2007·Annual Review of Ecology, Evolution, and Systematics·Scott D PletcherLinda Partridge
Jun 12, 2012·Dermatology Research and Practice·Jillian W Wong, John Y M Koo
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Jan 1, 2012·Longevity & Healthspan·Tamas FulopAnis Larbi
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Apr 2, 2020·Journal of Translational Medicine·Wei FangChao Zhang
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May 1, 2021·Vaccines·Yuxin YanCheng Heng Pang

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

Ingenuity Pathway
ZINCAGE
CIA

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