Age and mortality after injury: is the association linear?

European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society
R S FrieseP Rhee

Abstract

Multiple studies have demonstrated a linear association between advancing age and mortality after injury. An inflection point, or an age at which outcomes begin to differ, has not been previously described. We hypothesized that the relationship between age and mortality after injury is non-linear and an inflection point exists. We performed a retrospective cohort analysis at our urban level I center from 2007 through 2009. All patients aged 65 years and older with the admission diagnosis of injury were included. Non-parametric logistic regression was used to identify the functional form between mortality and age. Multivariate logistic regression was utilized to explore the association between age and mortality. Age 65 years was used as the reference. Significance was defined as p < 0.05. A total of 1,107 patients were included in the analysis. One-third required intensive care unit (ICU) admission and 48 % had traumatic brain injury. 229 patients (20.6 %) were 84 years of age or older. The overall mortality was 7.2 %. Our model indicates that mortality is a quadratic function of age. After controlling for confounders, age is associated with mortality with a regression coefficient of 1.08 for the linear term (p = 0.02) and a reg...Continue Reading

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Citations

Dec 16, 2020·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Karlijn J P van Wessem, Luke P H Leenen
Feb 13, 2021·The Journal of Nutrition, Health & Aging·V MoranH Israel

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