Age and Sex Are Critical Factors in Ischemic Stroke Pathology

Endocrinology
Meaghan Roy-O'Reilly, Louise D McCullough

Abstract

Ischemic stroke is a devastating brain injury resulting in high mortality and substantial loss of function. Understanding the pathophysiology of ischemic stroke risk, mortality, and functional loss is critical to the development of new therapies. Age and sex have a complex and interactive effect on ischemic stroke risk and pathophysiology. Aging is the strongest nonmodifiable risk factor for ischemic stroke, and aged stroke patients have higher mortality and morbidity and poorer functional recovery than their young counterparts. Importantly, patient age modifies the influence of patient sex in ischemic stroke. Early in life, the burden of ischemic stroke is higher in men, but stroke becomes more common and debilitating for women in elderly populations. The profound effects of sex and age on clinical ischemic stroke are mirrored in the results of experimental in vivo and in vitro studies. Here, we review current knowledge on the influence of age and sex in the incidence, mortality, and functional outcome of ischemic stroke in clinical populations. We also discuss the experimental evidence for sex and age differences in stroke pathophysiology and how a better understanding of these biological variables can improve clinical care a...Continue Reading

References

Jan 1, 1992·General Hospital Psychiatry·D S SchubertW Tamaklo
Jun 1, 1995·Australian and New Zealand Journal of Medicine·E G Stewart-Wynne, K Jamrozik
Jan 1, 1993·The American Journal of Psychiatry·P L MorrisT R Price
Jun 1, 1993·Stroke; a Journal of Cerebral Circulation·M S DennisC P Warlow
Feb 1, 1996·Stroke; a Journal of Cerebral Circulation·J TuomilehtoE Vartiainen
Jan 28, 1998·Stroke; a Journal of Cerebral Circulation·N J AlkayedP D Hurn
Jan 8, 2000·Stroke; a Journal of Cerebral Circulation·N J AlkayedV M Miller
Jan 21, 2000·Journal of the American Geriatrics Society·A ArboixC Targa
Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H V CarswellI M Macrae
May 8, 2000·Stroke; a Journal of Cerebral Circulation·G W PettyD O Wiebers
Jun 29, 2000·JAMA : the Journal of the American Medical Association·L A GillumS C Johnston
Nov 7, 2000·Journal of Neuroimmunology·P D Drew, J A Chavis
Mar 29, 2001·Obstetrics and Gynecology·A P MacKayH K Atrash
Jun 1, 2001·European Neurology·A ArboixC Targa
Oct 30, 2001·The New England Journal of Medicine·C M ViscoliR I Horwitz
Jul 2, 2002·JAMA : the Journal of the American Medical Association·Deborah GradyUNKNOWN HERS Research Group
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Dec 6, 2002·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Francesco CiprianiKim Bloomfield
Jan 4, 2003·Stroke; a Journal of Cerebral Circulation·Peter AppelrosMatti Viitanen
Apr 12, 2003·Stroke; a Journal of Cerebral Circulation·Antonio Di CarloUNKNOWN European BIOMED Study of Stroke Care Group
Jun 14, 2003·Stroke; a Journal of Cerebral Circulation·Jaume RoquerMeritxell Gomis
Jul 12, 2003·Stroke; a Journal of Cerebral Circulation·Eva-Lotta GladerUNKNOWN Riks-Stroke Collaboration
Jul 23, 2003·Neurology·Heather J FullertonS Claiborne Johnston
Feb 13, 2004·Age and Ageing·Lars Peter KammersgaardUNKNOWN Copenhagen Stroke Study
Aug 28, 2004·Stroke; a Journal of Cerebral Circulation·Jonathan W SturmAmanda G Thrift
Sep 29, 2004·Diabetes Care·Earl S FordAli H Mokdad
May 10, 2005·Stroke; a Journal of Cerebral Circulation·Maree L HackettCraig S Anderson
Sep 2, 2005·Obstetrics and Gynecology·Andra H JamesEvan R Myers
Sep 20, 2005·Journal of Neurology·H Bart van der WorpCor J Kalkman
Jan 18, 2006·International Journal of Clinical Practice·I IdrisJ C Sharma
Mar 15, 2006·Cardiovascular Research·Johannes A Moolman
Jun 1, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mingyue LiuNabil J Alkayed
Jun 21, 2006·Endocrine·Shotaro SuzukiPhyllis M Wise
Dec 21, 2006·Nature Reviews. Neuroscience·Michelle L BlockJau-Shyong Hong
Jun 22, 2007·Neurology·Amytis TowfighiBruce Ovbiagele
Jul 31, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J I RojasE Cristiano
Aug 4, 2007·Stroke; a Journal of Cerebral Circulation·Julia Warner GarganoUNKNOWN Paul Coverdell National Acute Stroke Registry Michigan Prototype Investigators

❮ Previous
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Citations

Oct 12, 2018·Cellular and Molecular Neurobiology·Rachida GuennounMichael Schumacher
Feb 15, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lars WinklerReiner F Haseloff
Jun 10, 2020·The Journal of Pharmacology and Experimental Therapeutics·Maricedes Acosta-Martinez
Jul 2, 2020·Biology of Sex Differences·Charly Abi-GhanemKristen L Zuloaga
Aug 28, 2020·Frontiers in Physiology·Moises Freitas-AndradeBaptiste Lacoste
Mar 29, 2020·Translational Stroke Research·Aishika DattaPallab Bhattacharya
Jul 9, 2020·Cells·Ádám MészárosIstván A Krizbai
May 20, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Rafal MorgaJoanna Pera
Nov 7, 2019·International Journal of Molecular Sciences·Laura CosteaIstván A Krizbai
Nov 3, 2020·American Journal of Physiology. Renal Physiology·Regina F SultanovaDaria V Ilatovskaya
Sep 30, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yuji IwamotoOsamu Araki
Jan 26, 2021·Stroke; a Journal of Cerebral Circulation·Anna K BonkhoffKlaus Berger
Feb 3, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Takashi OkadaUNKNOWN RELAXED study group
Sep 15, 2020·Brain, Behavior, and Immunity·Amanda CostaHelmut Kettenmann
Jul 9, 2020·Frontiers in Neuroendocrinology·Courtney E Stewart, Farida Sohrabji
Mar 27, 2021·Mechanisms of Ageing and Development·Julie A Chowen, Luis M Garcia-Segura
Apr 1, 2021·Cellular and Molecular Neurobiology·Devendra SinghK H Reeta
May 4, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mengnan LiuHua Zhou
Jun 26, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Javier de Miguel-DíezMarta López-Herranz
Jun 22, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jesús M PradilloIgnacio Lizasoain
Jul 30, 2021·Frontiers in Neuroscience·Klara J LohkampMaximilian Wiesmann
Dec 4, 2020·Aging and Disease·Anwen ShaoJianmin Zhang
Sep 11, 2021·Frontiers in Immunology·James P BarrettDavid J Loane
Oct 16, 2021·Journal of Neurology·Wenzhang LuoChangren Huang

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