Age and sex influences on airway hyperresponsiveness

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Ross McKenzieMimi L K Tang

Abstract

The precise relationship between age and gender and their influence on airway reactivity has not been clearly defined. Previous studies of age and gender influences on airway reactivity have been confounded by environmental influences such as cigarette smoking. The objective of this study was to examine the effect of age and gender on airway reactivity in C57BL/6 mice housed under controlled conditions, independent of confounding environmental factors. Mice were separated into four experimental groups based on age and gender: males at 6 and 12 weeks of age and females at 6 and 12 weeks of age. Airway reactivity to inhaled methacholine was examined in each group. Significant differences in methacholine-induced airway reactivity were observed between the sexes at both age groups. At 6 weeks of age, the males demonstrated a significantly increased airway reactivity to methacholine as compared to females (p <.001). Paradoxically, at 12 weeks of age, the males demonstrated a significantly lower response to methacholine as compared to females (p <.001). Hence the relationship between age and airway reactivity is markedly different in males as compared to females. Examination of intragender differences revealed that in female mice, ai...Continue Reading

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Citations

Dec 20, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Grace E HardieWarren M Gold
Nov 16, 2012·Inhalation Toxicology·Blake A BennettClarke G Tankersley
May 8, 2015·Pediatric Research·Catherine A MayerPeter M MacFarlane
Mar 31, 2015·Genomics·Tesfaye B MershaGurjit K Khurana Hershey
Oct 22, 2011·Respiratory Medicine·Amund RiiserKarin Lødrup Carlsen
Jul 6, 2014·BMC Pulmonary Medicine·Maria MatteisBruno D'Agostino
Oct 27, 2018·Expert Review of Respiratory Medicine·Andreas A TeferraH Marike Boezen
Dec 7, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Miguel Jo-AvilaJun Lu
Jun 22, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hua WangPeter M MacFarlane
Apr 20, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Su Kang KimJoo-Ho Chung

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