PMID: 6106564Aug 1, 1980Paper

Age and the role of certain mediators in the sensitivity of animals to hyperbaric oxygenation

Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova
T I BondarenkoA A Khodakova

Abstract

Dynamics of biologically active brain peptides: N-acetyl-1-aspartat-1-glutamat (NAAG) and homocarnosine (gamma-aminobutyric-1-histidine), aminoacids and their derivatives GABA, histidine and histamine, in the blood of rats and rabbits of different age under hyperoxia was studied. Exposure of animals to 4 atm of oxygen considerably decreased NAA and NAAG contents in the brain of 21 and 30-day old rats and induced the 85% and 47% decrease of homocarnosine and GABA contents respectively in the brain of 30-day old rabbits. Brain histidine and blood histamine contents increased in 14, 21 and 30-day old rabbits.

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