Age-appropriate compliance and completion of up to five doses of pertussis vaccine in US children

Human Vaccines & Immunotherapeutics
Girishanthy KrishnarajahPhilip O Buck

Abstract

In the United States (US), diphtheria, tetanus, and acellular pertussis (DTaP) vaccination is recommended at 2, 4, and 6 months (doses 1-3), 15-18 months (dose 4), and 4-6 years (dose 5). The objective of this study (GSK study identifier: HO-14-14383) was to examine DTaP completion and compliance rates among commercially insured and Medicaid-enrolled children. Secondarily, the study aimed at identifying predictors of compliance/completion. Truven Health MarketScan Commercial and Multi-State Medicaid databases (2005-2013) were analyzed separately. Children born during 2005-2011 with ≥ 2 years continuous enrollment from birth provided data for doses 1-4; those with continuous enrollment from birth to their seventh birthday provided dose 5 data. Series compliance (each recommended dose by 3, 5, and 7 months; 19 months; seventh birthday) and completion (3 doses by 8 months; 4 by 24 months; 5 by seventh birthday) were calculated. Predictors of compliance/completion were identified using multivariable logistic regression. A total of 367,493 commercially insured and 766,153 Medicaid-enrolled children were followed for ≥ 2 years; and 23,574 and 41,284, respectively, for ≥ 7 years. Series compliance to doses 1-3, 1-4, and 1-5 were 67.2%...Continue Reading

References

Jul 3, 2004·Pediatrics·Philip J SmithLawrence E Barker
Mar 10, 2005·JAMA : the Journal of the American Medical Association·Elizabeth T LumanLarry K Pickering
Mar 15, 2006·Ambulatory Pediatrics : the Official Journal of the Ambulatory Pediatric Association·Matilde M IrigoyenEneida Mendonca
Aug 8, 2006·Vaccine·Sarah TicknerAlison Woodcock
May 29, 2007·The Pediatric Infectious Disease Journal·Gary S MarshallArgartha Russell
Jan 17, 2009·The Pediatric Infectious Disease Journal·Laura E HappeGary S Marshall
May 6, 2009·Archives of Pediatrics & Adolescent Medicine·Philip J SmithNoelle-Angelique Molinari
Oct 5, 2011·Pediatrics·Amanda F DempseyGary L Freed
Oct 14, 2011·The New England Journal of Medicine·Jennifer E CortesUmesh D Parashar
May 25, 2013·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Scott D GrosseMarie E Faughnan
Oct 2, 2013·Pediatrics·Jessica E AtwellSaad B Omer
Nov 6, 2013·Pediatrics·Douglas J OpelJeffrey D Robinson
Jun 21, 2015·Vaccine·Neal D GoldsteinSeth L Welles
Jun 25, 2015·BMC Medicine·Benjamin M Althouse, Samuel V Scarpino
May 31, 2017·Pediatrics·Brendan FlanneryAlicia M Fry

❮ Previous
Next ❯

Citations

Feb 19, 2020·Current Opinion in Pediatrics·Nicola BrodieElizabeth A Silberholz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.