Age as a prognostic factor in recurrent breast cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
G FalksonF J Pretorius

Abstract

The effect of age as a prognostic factor in recurrent breast cancer was studied in 1,168 patients treated on Eastern Cooperative Oncology Group (ECOG) protocols. Survival was significantly shorter in patients less than 35 years of age (P = .03). This was true even when other good prognostic factors were present. Eighteen prognostic factors were analyzed, and the effect on survival in each of six age groups was studied. Patients with better performance status, less than three sites of metastases, and without visceral or nodal metastases had a better survival time. A Cox proportional hazards model of survival showed that younger age groups, irrespective of menopausal status, had shorter survival times. The predicted median survival times after the first recurrence were 491 days for patients less than 35 years of age, 590 days for patients 36 to 45 years of age, and 700 days for those greater than 45 years of age.

Citations

Apr 1, 1991·The Australian and New Zealand Journal of Surgery·I C BennettI S Fentiman
Oct 1, 1989·Statistics in Medicine·A Cnaan, L Ryan
Apr 28, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dan TongRobert Zeillinger

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