Age-associated alterations in the micromechanical properties of chromosomes in the mammalian egg

Journal of Assisted Reproduction and Genetics
Jessica E HornickTeresa K Woodruff

Abstract

The incidence of aneuploidy in eggs from women of advanced reproductive age can exceed 60%, making the mammalian egg a unique model system to study the mechanisms of chromosome segregation errors. Here we applied a novel biophysical chromosome stretching approach to quantify mechanical stiffness of meiotic chromosomes in the mammalian egg and then documented how these properties changed in a mouse model of physiologic reproductive aging. We found significant differences in chromosome micromechanics, and thus in higher order chromosome structure, coincident with advanced reproductive age, a time that is also unequivocally associated with an increase in egg aneuploidy. These findings have important implications for both reproductive and cancer biology where aneuploidy plays a central role in aging related disease states.

References

Sep 10, 2003·Current Topics in Developmental Biology·M G Poirier, John F Marko
May 8, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·John F Marko
Nov 3, 2009·Current Opinion in Pediatrics·Terry Hassold, Patricia Hunt
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Mar 3, 2010·The Journal of Cell Biology·Ryo KawamuraJohn F Marko
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Feb 9, 2011·Physical Biology·Mingxuan SunJohn F Marko
Jul 25, 2012·Aging Cell·Francesca E DuncanTeresa K Woodruff
Aug 29, 2013·Development·Keith T Jones, Simon I R Lane

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Citations

May 6, 2016·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Adrienne EastlandJohn F Marko
Aug 6, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Shawn M BrileyFrancesca E Duncan
Oct 11, 2017·Aging Cell·Francesca E DuncanJennifer L Gerton
Oct 26, 2016·Current Opinion in Endocrinology, Diabetes, and Obesity·Kara N Goldman, Jamie A Grifo
Jun 14, 2019·Reproductive Biology and Endocrinology : RB&E·Shweta S DipaliFrancesca E Duncan
Jan 31, 2021·Chemosphere·Hunter B RogersTeresa K Woodruff
Jun 3, 2021·International Journal of Molecular Sciences·Jordan H MachlinFrancesca E Duncan

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