Age-associated changes in Ca(2+)-dependent processes: relation to hippocampal synaptic plasticity

Hippocampus
T C Foster, C M Norris

Abstract

Altered calcium (Ca2+) homeostasis is thought to play a key role in aging and neuropathology resulting in memory deficits. Several forms of hippocampal synaptic plasticity are dependent on Ca2+, providing a potential link between altered Ca2+ homeostasis and memory deficits associated with aging. The current study reviews evidence for Ca2+ dysregulation during aging which could interact with Ca(2+)-dependent synaptic plasticity. The authors suggest that changes in Ca2+ regulation could adjust the thresholds for synaptic modification, favoring processes for depression of synaptic strength during aging.

References

Feb 1, 1979·Journal of Comparative and Physiological Psychology·C A Barnes
Oct 19, 1979·Brain Research·W B Levy, O Steward
Oct 20, 1977·Journal of Mathematical Biology·T J Sejnowski
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S M Dudek, M F Bear
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D S KerrP W Landfield
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J H Wang, D P Feng
Mar 1, 1992·Mechanisms of Ageing and Development·M L MichaelisC Jayawickreme
Mar 1, 1991·Neurobiology of Aging·G L WenkL C Cork
Sep 1, 1991·Neurobiology of Aging·T C FosterB L McNaughton
May 1, 1991·Neurobiology of Aging·D A Turner, D L Deupree
Sep 1, 1990·Neurobiology of Aging·F BattainiM Trabucchi
Jan 29, 1990·Brain Research·T Konishi
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J Lisman
Jul 1, 1987·Behavioral and Neural Biology·M R FoyR F Thompson
Sep 1, 1988·Neurobiology of Aging·L deToledo-MorrellF Morrell
Apr 1, 1984·Mechanisms of Ageing and Development·M L MichaelisT E Kitos

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Citations

Oct 23, 2002·Journal of Neuroscience Research·Bruce Teter, J Wesson Ashford
Jan 15, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Gerhard EichhoffOlga Garaschuk
Dec 3, 2013·European Journal of Pharmacology·J C GantP W Landfield
Nov 24, 1999·Brain Research. Brain Research Reviews·T C Foster
Sep 23, 2000·Behavioural Brain Research·W H GriffithD Murchison
Jan 24, 2002·Neurobiology of Aging·William AlmaguerJorge A Bergado
Dec 25, 2002·Neurobiology of Aging·Ayako M Watabe, Thomas J O'Dell
Aug 21, 2003·Neurobiology of Aging·Thomas C FosterJames Masse
Dec 22, 1999·Neurobiology of Aging·C E Finch, R M Sapolsky
May 22, 2003·Progress in Neurobiology·Ephron S Rosenzweig, Carol A Barnes
Feb 17, 2001·Brain Research Bulletin·R M VouimbaR F Thompson
Dec 13, 2000·Experimental Gerontology·B PotierJ M Billard
Feb 2, 2002·Free Radical Biology & Medicine·J A JosephJ Strain
Dec 24, 2005·Nature Reviews. Neuroscience·Sara N Burke, Carol A Barnes
Aug 12, 2014·Age·Brandon H CherryRobert T Mallet
May 6, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher M NorrisSusan D Kraner
May 4, 2011·World Journal of Biological Chemistry·Asma Zaidi
Oct 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ashok Kumar, Thomas C Foster
Mar 14, 2003·Journal of Neurophysiology·David J FrocBrian R Christie
Sep 6, 2013·Journal of Neurophysiology·Ann-Maree Vallence, Mitchell R Goldsworthy
Apr 7, 2020·Reviews in the Neurosciences·Diana Marcela Cuestas Torres, Fernando P Cardenas
Aug 27, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Thomas C Foster, Ashok Kumar

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