Age-associated changes in CD90 expression on thymocytes and in TCR-dependent stages of thymocyte maturation in male rats

Experimental Gerontology
G LeposavićB Plećas-Solarović

Abstract

To elucidate the effects of ageing on T-cell-maturation, in 3- and 18-month-old rats, we analysed the expression of: (i) CD4/CD8/TCRalphabeta and (ii) Thy-1, which is supposed to be a regulator of TCRalphabeta signalling, and thereby the thymocyte selection thresholds. Since an essential role for TCRalphabeta signalling in the development of CD4+25+T(reg)-cells was suggested, the frequency of these cells was also quantified. We demonstrated that, as for mice, early thymocyte differentiational steps within the CD4-8- double negative (DN) developmental stage are age-sensitive. Furthermore, we revealed that TCRalphabeta-dependent stages of T-cell development are affected by ageing, most likely due to an impaired expression of Thy-1 on TCRalphabeta(low) thymocytes entering selection processes. The diminished frequency of the post-selection CD4+8+ double positive (DP) cells in aged rats, together with an overrepresentation of mature single positive (SP) cells, most probably suggests more efficient differentiational transition from the DP TCRalphabeta(high) to the SP TCRalphabeta(high) developmental stage, which is followed by an increase in pre-migration proliferation of the mature SP cells. Moreover, the study indicated impaired in...Continue Reading

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Citations

Apr 20, 2010·Biogerontology·Nebojša DespotovićM Davidović
Jun 19, 2012·Immunobiology·Milica PerišićGordana Leposavić
Dec 17, 2009·Journal of Comparative Pathology·D AwD B Palmer
Jul 7, 2009·Immunobiology·Milica PerisićGordana Leposavić
Jun 23, 2009·Trends in Immunology·Daryl P ShanleyDonald B Palmer
Jun 24, 2009·Experimental Biology and Medicine·Zorica Stojić-VukanićGordana Leposavić
May 24, 2019·Biogerontology·Mirjana Nacka-AleksićGordana Leposavić

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