Age-associated changes of responses to acetylsalicylic acid

Pain
Steven I BaskinAllan H Goldfarb

Abstract

Aspirin can be an effective antipyretic, analgesic and anti-inflammatory agent, but unfortunately, its use in the elderly is often excessive [43]. In a survey by Gillies and Skyring, the overall prevalence of daily aspirin intake was greater in middle-age and older-age groups than for those of less than 40 years of age [16]. The elderly are susceptible to the advertising of non-prescription drugs and aspirin is frequently self-prescribed [8,31]. Age-related physiological changes modify the response to aspirin in the elderly. A higher incidence of drug reactions and interactions has been evidenced in this age group. The cases cited throughout this report substantiate the need for caution on the part of the geriatric patient and the physician in regard to aspirin therapy for the elderly.

References

Oct 1, 1975·Agents and Actions·K D Rainsford
Dec 10, 1977·British Medical Journal·R Gokal, D R Matthews
Nov 15, 1975·Lancet·J Mendelson, S Grisolia
Sep 1, 1976·Journal of the American Geriatrics Society·T E Hunt
Jan 1, 1978·Experimental Gerontology·L S Birnbaum, M B Baird
Feb 1, 1979·The Gerontologist·L R Krupka, A M Vener
Sep 26, 1977·JAMA : the Journal of the American Medical Association·J A Ingelfinger, P Goldman
Oct 1, 1978·American Journal of Ophthalmology·C J AndersonR J Sturm
Oct 1, 1978·Journal of Clinical Pharmacology·R R Miller
Sep 1, 1977·Comprehensive Psychiatry·H M van Praag
Aug 1, 1976·British Journal of Pharmacology·E Mielens, F J Rosenberg
May 3, 1975·British Medical Journal·E C Hammond, L Garfinkel
Jul 1, 1972·Clinical Pharmacology and Therapeutics·R B Stewart, L E Cluff
Mar 9, 1974·British Medical Journal
Jan 1, 1972·Annals of the Rheumatic Diseases·H C Burry
May 6, 1972·The Medical Journal of Australia·M A Gillies, A P Skyring
Jun 26, 1971·British Medical Journal·M Lee-Jones
Dec 14, 1968·British Medical Journal·H B ValmanN F Coghill
Apr 18, 1970·The Medical Journal of Australia·J M Duggan, B L Chapman
Nov 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·A Gottschalk, R Menguy
May 22, 1971·British Medical Journal·A S RussellM A Smith
Apr 1, 1968·Archives of Otolaryngology·L F Perez de Moura, R C Hayden
May 1, 1968·Annals of Internal Medicine·M Samter, R F Beers
Aug 1, 1978·The Physician and Sportsmedicine·M L PollockP M Ribisl

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Citations

May 1, 1993·British Journal of Clinical Pharmacology·A G JohnsonJ McCallum

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