DOI: 10.1101/478438Nov 27, 2018Paper

Age-associated different transcriptome profiling in zebrafish and rat: insight into diversity of vertebrate aging

BioRxiv : the Preprint Server for Biology
Yusuke KijimaShigeharu Kinoshita

Abstract

Background: Aging and death are inevitable for most species and are of intense interest for human beings. Most mammals, including humans, show obvious aging phenotypes, for example, loss of tissue plasticity and sarcopenia. In this regard, fish provide attractive models because of their unique aging characteristics. First, the lifespan of fish is highly varied and some long-lived fish can live for over 200 years. Second, some fish show anti-aging features and indeterminate growth throughout their life. Because these characteristics are not found in mammalian model organisms, exploring mechanisms of senescence in fish is expected to provide new insights into vertebrate aging. Therefore, we conducted transcriptome analysis for brain, gill, heart, liver and muscle from 2-month-, 7-month-, 16-month- and 39-month-old zebrafish. In addition, we downloaded RNA-seq data for sequential age-related gene expression in brain, heart, liver and muscle of rat (1). These RNA-seq data from two species were compared, and common and species-specific features of senescence were analyzed. Results: Screening of differentially expressed genes (DEGs) in all zebrafish tissues examined revealed up-regulation of circadian genes and down-regulation of hmg...Continue Reading

Related Concepts

Aging
Autophagy
Brain
Cessation of Life
Down-Regulation
Gene Expression
Genes
Heart
Liver
Muscle

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