PMID: 24334613Dec 18, 2013Paper

Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells

Aging
Paul R ColemanJennifer R Gamble

Abstract

Age is the greatest risk factor for cardiovascular disease. In addition, inflammation and age (senescence) have been linked at both the clinical and molecular levels. In general, senescent cells have been described as pro-inflammatory based on their senescence associated secretory phenotype (SASP). However, we have previously shown that senescence induced by overexpression ofSENEX (or ARHGAP18), in endothelial cells results in an anti-inflammatory phenotype. We have investigated, at the individual cellular level, the senescent phenotype of endothelial cells following three of the chief signals associated with ageing; oxidative stress, disturbed flow and hypoxia. All three stimuli induce senescence and, based on neutrophil adhesion and expression of the adhesion molecules E-selectin and VCAM-1, a population of senescent cells is seen that is resistant to inflammatory stimuli and thus we define as anti-inflammatory. The proportion of anti-inflammatory cells increases with time but remains stable at approximately 50% by eight days after induction of senescence, suggesting that these are stable phenotypes of endothelial cell senescence. Similar to other senescent cell types, p38MAPK blockade inhibits the development of the pro-infl...Continue Reading

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Citations

Aug 23, 2016·FEBS Letters·Soojeong ChangHyunsung Park
Sep 21, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hisaaki KobayashiAkihiro Yoshino
Nov 7, 2017·Oxidative Medicine and Cellular Longevity·Sandro SattaStephen J White
Nov 20, 2014·Aging Cell·Elizabeth E PowterJennifer R Gamble
Mar 3, 2017·Molecular Biology of the Cell·Michael D LovelaceJennifer R Gamble
Jan 12, 2019·Journal of the American Heart Association·Angelina J LayJennifer R Gamble
Feb 6, 2020·Cell Communication and Signaling : CCS·Paul R ColemanJennifer R Gamble
Nov 27, 2014·Cell Cycle·Valeria GasperiMaria Valeria Catani
Sep 24, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yi-Fan ChenTammy R Dugas
Apr 29, 2015·The Journal of Endocrinology·Bo ChenJingqiu Cheng
Oct 13, 2020·Frontiers in Neurology·Annie G BryantRachel E Bennett
Mar 2, 2021·Pathology, Research and Practice·Zuo-Long WuHai-Hong Zhang
Jul 3, 2021·International Journal of Molecular Sciences·Alla N ShatrovaAleksandra V Borodkina
Apr 14, 2017·Journal of Agricultural and Food Chemistry·Amrita ChaudharyJyotirmoy Chatterjee

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