Age at diagnosis and age at death in familial prostate cancer

The Oncologist
Andreas BrandtKari Hemminki

Abstract

A family history of prostate cancer is associated with a higher risk for prostate cancer to first-degree relatives. If greater surveillance of men at familial risk is considered to be useful, population-based estimates of the differences in the age at diagnosis between familial and sporadic prostate cancer cases are needed. The men in the nationwide Swedish Family-Cancer Database were classified according to the number and type of affected first-degree relatives (father or brother) and according to the relative's age at diagnosis. The cumulative incidence of prostate cancer and cumulative prostate cancer-specific mortality were estimated using a stratified Cox model. The cumulative incidence was highest for men with multiple affected first-degree relatives, and it was higher for brothers than for sons of prostate cancer patients. The age to reach the same cumulative incidence as the general population at age 55 years decreased with decreasing age at diagnosis of the relative, ranging from 48.7 years (father diagnosed before 60 years of age) to 53.7 years (father diagnosed after 82 years of age). Prostate cancer-specific mortality was also related to the number and type of affected relatives but there was no clear evidence for a...Continue Reading

References

Oct 9, 2001·Epidemiologic Reviews·J L Stanford, E A Ostrander
Mar 19, 2003·Lancet·Henrik Grönberg
Dec 17, 2003·Scandinavian Journal of Urology and Nephrology·Pär StattinJan-Erik Johansson
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Kari HemminkiJusto Lorenzo Bermejo
Oct 21, 2006·Lifetime Data Analysis·Tze Leung Lai, Zheng Su
Aug 6, 2008·Annals of Internal Medicine·UNKNOWN U.S. Preventive Services Task Force
Dec 24, 2008·Nature Reviews. Genetics·John S Witte
Mar 12, 2009·Journal of the National Cancer Institute·Gerrit DraismaHarry de Koning
Mar 20, 2009·The New England Journal of Medicine·Michael J Barry
Mar 20, 2009·The New England Journal of Medicine·Gerald L AndrioleUNKNOWN PLCO Project Team
Mar 20, 2009·The New England Journal of Medicine·Fritz H SchröderUNKNOWN ERSPC Investigators
Jun 2, 2009·European Urology·Per-Anders AbrahamssonManfred Wirth

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Citations

Nov 26, 2011·World Journal of Urology·Kari Hemminki
Dec 7, 2013·Journal of Genetic Counseling·Elizabeth HandorfVeda N Giri
Sep 30, 2010·Acta Oncologica·Giuseppe Colloca, Antonella Venturino
Dec 27, 2011·Pathology·Ken Sikaris
Aug 5, 2015·The Journal of Urology·Johannes M S BrathKathleen Herkommer
Feb 11, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Masaki ShiotaUNKNOWN Japan Study Group of Prostate Cancer (J-CaP)
Jun 1, 2016·Reviews on Environmental Health·João F S SilvaRicardo D Aydos
Apr 29, 2015·World Journal of Gastroenterology : WJG·Hee-Won KwakYoung-Woo Kim
Jul 28, 2020·International Journal of Molecular Sciences·Andreia BrandãoManuel R Teixeira
Jun 12, 2014·Revista brasileira de epidemiologia = Brazilian journal of epidemiology·João Francisco Santos da SilvaRicardo Dutra Aydos
Aug 9, 2021·European Urology Oncology·Hendrik Van PoppelMonique J Roobol

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