Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis

Rheumatology International
Ernst FeldtkellerJürgen Braun

Abstract

To investigate differences between HLA-B27(-) and HLA-B27(+) patients with ankylosing spondylitis (AS). A total of 1080 patients with AS responded to a questionnaire containing 30 questions; 945 (87.5%) knew their HLA-B27 status, 10% of them being B27(-). The average age at disease onset was 27.7 years in B27(-) and 24.8 years in B27(+) AS (P < 0.01). The average age at diagnosis was 39.1 and 33.2 years and the average diagnosis delay 11.4 and 8.5 years, respectively. The distribution in age at disease onset was significantly wider in B27(-) (standard deviation 10.0 years) than in B27(+) AS (8.3 years). The percentages with childhood (age < 16 years) disease onset did not differ significantly (7.6% vs. 6.2%, respectively), whereas the percentage of late onset (age > 40 years) was significantly greater among B27(-) (13%) than among B27(+) (5%) patients with AS. There is a difference in average age at disease onset between male (25.7 years) and female (24.2 years) AS patients, and no difference between patients with primary AS and AS associated with psoriasis, inflammatory bowel disease, or reactive arthritis. Acute anterior uveitis was significantly less frequent in B27(-) (26%) than in B27(+) (41%) patients with AS. CONCLUSIONS...Continue Reading

Citations

May 13, 2014·Rheumatology International·Ediz DalkılıçMustafa Yurtkuran
Apr 15, 2004·Annals of the Rheumatic Diseases·M RudwaleitJ Sieper
May 19, 2005·Arthritis Research & Therapy·Hing Wo TsuiFlorence W L Tsui
Oct 22, 2005·Annals of the Rheumatic Diseases·J Sieper, M Rudwaleit
Jan 31, 2007·Annals of the Rheumatic Diseases·Bert Vander CruyssenNathan Vastesaeger
Apr 26, 2007·Annals of the Rheumatic Diseases·Henning Christian BrandtJoachim Sieper
Feb 12, 2009·Rheumatology·Marena Rojas-VargasUNKNOWN Registro Español de Espondiloartritis de la Sociedad Española de Reumatología Working Group
Feb 24, 2009·Arthritis Research & Therapy·Joachim Sieper
Jul 8, 2010·Nature Reviews. Rheumatology·Robert A Colbert
Aug 11, 2010·Clinical Rheumatology·M A C van der WeijdenI E van der Horst-Bruinsma
Jul 30, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ranganathan ArunH Mehdian
Apr 8, 2017·Current Rheumatology Reports·Nurullah AkkoçMuhammad A Khan
Apr 25, 2006·Clinical Rheumatology·Jane ZochlingJürgen Braun
Aug 10, 2006·Current Opinion in Rheumatology·Lianne Gensler, John C Davis
Nov 23, 2006·Zeitschrift für Rheumatologie·C E AlthoffJ Sieper
Dec 15, 2006·Genes and Immunity·A-M SimsM A Brown
Mar 20, 2010·BMC Musculoskeletal Disorders·Mary J BellGeorge A Wells
Mar 16, 2004·Current Rheumatology Reports·Désirée van der Heijde
Mar 12, 2005·Rheumatology International·Ernst FeldtkellerSjef van der Linden
Oct 5, 2007·Current Rheumatology Reports·Rubén Burgos-Vargas
Oct 5, 2007·Current Rheumatology Reports·In-Ho SongMartin Rudwaleit
Dec 13, 2007·Rheumatology International·Ernst Feldtkeller, Jon Erlendsson
Mar 1, 2008·Proteomics. Clinical Applications·Stijn LambrechtDieter Deforce
Apr 9, 2005·Arthritis and Rheumatism·Martin RudwaleitJoachim Sieper
Mar 1, 2008·The Korean journal of laboratory medicine·Kyung Sun ParkWoo In Lee
May 27, 2008·Wiener medizinische Wochenschrift·Christian DejacoMichael Schirmer
May 27, 2008·Wiener medizinische Wochenschrift·Martin Rudwaleit
Sep 27, 2008·Current Rheumatology Reports·Heiner Appel, Joachim Sieper
Dec 5, 2008·Clinical Rheumatology·Rohit Aggarwal, Anand N Malaviya
Dec 23, 2008·Nature Clinical Practice. Rheumatology·Aileen M DavisMonique A Gignac

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