Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers

Breast Cancer Research and Treatment
Joanne KotsopoulosHereditary Breast Cancer Clinical Study Group

Abstract

In the general population, an early age at first full-term birth confers protection against the risk of developing breast cancer. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Thus, we undertook a case-control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors. Information about reproductive factors, including age at first birth as well as medical history, was collected from a routinely administered research questionnaire. There were 2,295 matched pairs of women with a BRCA1 or BRCA2 mutation included in the final analysis. There was no significant difference in the mean age at first full-term birth among the BRCA1 (24.9 vs. 25.2; P = 0.10) or BRCA2 mutation carriers (26.5 vs. 26.6 years; P = 0.80). Findings were similar in the analysis limited to cases who were diagnosed with breast cancer prior to age 45. This matched analysis of a large number of BRCA mutation carriers suggests that age at first birth has little influence on BRCA1 or BRCA2 breast cancer risk.

References

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Citations

Mar 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Samuel V Scarpino, Benjamin M Althouse
Feb 17, 2019·Breast Cancer Research : BCR·Bastien NguyenChristos Sotiriou
Mar 8, 2020·Canadian Journal of Public Health = Revue Canadienne De Santé Publique·Emily HeerDarren R Brenner
Aug 10, 2020·Cancer·Emily V HeerMiranda M Fidler-Benaoudia
Aug 20, 2019·Reproductive Toxicology·Jasmine A McDonaldMary Beth Terry
Dec 29, 2020·Clinical Breast Cancer·Eleonora BrunoPatrizia Pasanisi

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