Age at menarche and adult body mass index: a Mendelian randomization study

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Dipender GillCosetta Minelli

Abstract

Pubertal timing has psychological and physical sequelae. While observational studies have demonstrated an association between age at menarche and adult body mass index (BMI), confounding makes it difficult to infer causality. The Mendelian randomization (MR) technique is not limited by traditional confounding and was used to investigate the presence of a causal effect of age at menarche on adult BMI. MR uses genetic variants as instruments under the assumption that they act on BMI only through age at menarche (no pleiotropy). Using a two-sample MR approach, heterogeneity between the MR estimates from individual instruments was used as a proxy for pleiotropy, with sensitivity analyses performed if detected. Genetic instruments and estimates of their association with age at menarche were obtained from a genome-wide association meta-analysis on 182,416 women. The genetic effects on adult BMI were estimated using data on 80,465 women from the UK Biobank. The presence of a causal effect of age at menarche on adult BMI was further investigated using data on 70,692 women from the GIANT Consortium. There was evidence of pleiotropy among instruments. Using the UK Biobank data, after removing instruments associated with childhood BMI tha...Continue Reading

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Citations

Jun 6, 2019·Biology Letters·Peter LenártJulie Bienertová-Vašků
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Jun 3, 2021·International Journal of Environmental Research and Public Health·Barry GerberAnkebe Kruger

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