Age at natural menopause and physical function in older women from Albania, Brazil, Colombia and Canada: A life-course perspective

Maturitas
Maria P VelezCatherine McLean Pirkle

Abstract

Grip strength and gait speed are objective measures of physical function, which in turn is an indicator of biological aging. We evaluate the association between age at natural menopause (ANM) and physical functioning in a sample of postmenopausal women drawn from the International Mobility in Aging Study (IMIAS). Retrospective cohort study of 775 women aged 65-74, from Albania, Brazil, Colombia and Canada, who had experienced natural menopause. Gait speed and grip strength were obtained following standardized protocols. The association between self-reported ANM (<40, 40-44, 45-49, 50-54 and ≥55) and gait speed (m/s) and grip strength (kg) was assessed by linear regression analyses adjusting for several life-course economic and reproductive exposures, height, BMI and smoking. Overall, women with ANM ≥ 55 had higher gait speed than those with ANM 50-54 (β = 0.05; 95%CI: 0.01, 0.10). Women with ANM < 40 had significantly lower grip strength compared with all other groups (β= -2.58; 95%CI: -4.43, -0.74). In region-specific analyses, ANM was associated with grip strength in Albania and Latin America and with gait speed in Albania only. No associations were observed in Canada. ANM is associated with markers of physical functioning. D...Continue Reading

Citations

May 28, 2019·Menopause : the Journal of the North American Menopause Society·Maria P VelezCatherine M Pirkle
Jul 24, 2020·Menopause : the Journal of the North American Menopause Society·Haihui RuanYanhong Wang
Mar 29, 2020·Biomédica : revista del Instituto Nacional de Salud·Jennyfer BenavidesMaría Magdalena Echeverry
Aug 28, 2019·Menopause : the Journal of the North American Menopause Society·Maria P VelezCatherine M Pirkle
Oct 5, 2019·International Journal of Occupational Safety and Ergonomics : JOSE·Dorota RaczkiewiczEwa Humeniuk
Jan 6, 2021·Menopause : the Journal of the North American Menopause Society·Pedro Rafael de Souza MacêdoSaionara Maria Aires da Câmara

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