Age, Body Mass Index, and Gender Predict 24-Hour Urine Parameters in Recurrent Idiopathic Calcium Oxalate Stone Formers

Journal of Endourology
Brandon J OttoBenjamin Canales

Abstract

Despite guidelines, routine 24-hour urine testing is completed in <10% of high-risk, recurrent stone formers. Using surrogates for metabolic testing, such as key patient characteristics, could obviate the cost and burden of this test while providing information needed for proper stone prevention counseling. We performed a retrospective study of 392 consecutive patients from 2007 to 2014 with ≥2 lifetime stone episodes, >70% calcium oxalate by mineral analysis, and ≥1 24-hour urine collection. We compared mean 24-hour urine values by age in decades. We used logistic regression and receiver operating characteristic (ROC) curve analysis to assess the predictive ability of age, gender, body mass index (BMI), and comorbidities to detect abnormal 24-hour urine parameters. The mean age of the cohort was 51 ± 16 years. Older age was associated with greater urinary oxalate (p-trend <0.001), lower urinary uric acid (UA) (p-trend = 0.007), and lower urinary pH (p-trend <0.001). A nonlinear association was noted between age and urinary calcium or citrate (calcium peaked at 40-49 years, p = 0.03; citrate nadired at 18-29 years, p = 0.001). ROC analysis of age, gender, and BMI to predict 24-hour urine abnormalities performed the best for hyp...Continue Reading

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Citations

Mar 12, 2019·Current Opinion in Urology·Mehmet ÖzsoyPanagiotis Kallidonis
May 3, 2019·Current Opinion in Nephrology and Hypertension·Orhan EfeSushrut S Waikar
Apr 25, 2019·American Journal of Physiology. Renal Physiology·Cameron J MenezesBenjamin Ko
Mar 9, 2021·Seminars in Nephrology·Emmanuel Adomako, Orson W Moe
Mar 21, 2021·International Journal of Hematology·Shinichiro KawaguchiYoshinobu Kanda
Dec 10, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Daniel G FusterNasser A Dhayat
Nov 14, 2020·Scandinavian Journal of Urology·Linda My HuynhRamy F Youssef

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Methods Mentioned

BETA
urine collection

Software Mentioned

Statistical Analysis Software ( SAS )
EQUIL

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