DOI: 10.1101/473363Nov 19, 2018Paper

Age but not disease progression defines CD4+ and CD8+ T stem cell memory levels in human retroviral infections: contrasting effects of HTLV-1 and HIV-1

BioRxiv : the Preprint Server for Biology
Soraya Maria MenezesJohan Van Weyenbergh


Background: Human CD4+ and CD8+ stem cell memory T cells (TSCM) represent a minor fraction of circulating lymphocytes characterized by stemness and long-term in vivo persistence. CD4+ TSCM are preferentially infected and constitute a reservoir for HIV-1, whereas CD8+ TSCM appear to play a protective role. However, little is known about CD4+ and CD8+ TSCM in the only other human pathogenic retroviral infection, human T-cell leukemia virus type 1 (HTLV-1). HTLV-1 is the etiological agent of both Adult T-cell Leukemia (ATL) and HTLV-1 associated myelopathy/tropical spastic paraperesis (HAM/TSP), a neuroinflammatory disorder. In ATL, CD4+ TSCM cells were identified as the hierarchical leukemic stem cell, but data in HAM/TSP are lacking. Age is a major risk factor for both ATL and HAM/TSP, as both diseases generally manifest several decades after infection. Therefore, we explored a possible link between TSCM, age and disease status in human retroviral infections in a cross-sectional study, using multiparametric flow cytometry. Results: We found that CD4+ or CD8+ TSCM levels (quantified as CD3+CD45RA+CD45RO-CD27+CCR7+Fashi) do not differ between healthy controls and untreated HTLV-1 infected individuals with and without neuroinflamma...Continue Reading

Related Concepts

Cross-Sectional Studies
HTLV-I Antibodies
HTLV-I Antigens
HTLV-I Infections
Leukemia, T-Cell
Adult T-Cell Lymphoma/Leukemia
Tropical Spastic Paraparesis

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