PMID: 3215297Dec 1, 1988Paper

Age changes in rhesus monkey ciliary muscle: light and electron microscopy

Experimental Eye Research
E Lütjen-DrecollP L Kaufman

Abstract

The ciliary muscle from 44 rhesus monkeys ranging in age from 137-day fetuses and a 3-week neonate to 35-year-old adults was studied by light and electron microscopy. In the fetuses and the neonate, the muscle cells appeared immature, and the muscle consisted mainly of longitudinally oriented fibers. By age 1 year, the muscle fibers were aggregated into bundles, and within each bundle the individual fibers were packed tightly together. In sagittal section, the muscle now exhibited longitudinal, reticular and circular portions. The individual muscle cells exhibited ultrastructural characteristics which set them apart from other smooth muscle cells. Age-related structural changes occurred in the ciliary muscle and intramuscular nerves, beginning at 6 years. These included increasing numbers of lysosomes, 'fingerprints', and the appearance of myelin figures within some nerve endings and nerve fibers. These alterations became more frequent and pronounced with age, and in elderly animals were seen in all regions of the muscle and around its entire circumference. Additionally, the elderly animals exhibited overt degeneration of some muscle cells and some myelinated nerve fibers. The time-course of these age-related structural neuromu...Continue Reading

References

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Citations

Jul 1, 1991·Pflügers Archiv : European journal of physiology·F StahlM Wiederholt
Jan 24, 2007·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·E Lütjen-Drecoll, F E Kruse
Jul 3, 2008·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M Baumeister, T Kohnen
Feb 1, 1992·Mechanisms of Ageing and Development·S TammJ W Rohen
May 28, 2005·Progress in Retinal and Eye Research·B'Ann True Gabelt, Paul L Kaufman
Nov 1, 1995·Experimental Eye Research·S KamikawatokoA Ishida
Apr 6, 2001·International Ophthalmology Clinics·M A CroftP L Kaufman
May 5, 2000·Optometry and Vision Science : Official Publication of the American Academy of Optometry·M T Pardue, J G Sivak
Jul 11, 2001·Optometry and Vision Science : Official Publication of the American Academy of Optometry·A GlasserP L Kaufman
Jul 26, 2002·Journal of Glaucoma·Carol B TorisCarl B Camras
Apr 17, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Helen Annie LewisMelissa D Bailey
Jun 8, 2013·Investigative Ophthalmology & Visual Science·Mary Ann CroftPaul L Kaufman
Feb 14, 2016·Japanese Journal of Ophthalmology·Sang Wook Jin, Ji Sang Min
Feb 18, 2010·Experimental Eye Research·Mark Wendt, Adrian Glasser
Dec 31, 2008·Experimental Eye Research·Ozan-Yüksel Tektas, Elke Lütjen-Drecoll
Nov 4, 2006·Journal of Cataract and Refractive Surgery·Susan A StrenkSuqin Guo
Sep 24, 2013·Progress in Retinal and Eye Research·Sarah F JanssenArthur A B Bergen
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Jan 24, 2002·Vision Research·Abhiram S Vilupuru, Adrian Glasser
Apr 29, 2008·American Journal of Ophthalmology·Kyung-Ah ParkChangwon Kee
Feb 15, 2005·Progress in Retinal and Eye Research·Susan A StrenkJane F Koretz
May 1, 2019·Investigative Ophthalmology & Visual Science·Paul L KaufmanMary Ann Croft
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May 26, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Şahbender Koç, Sadettin Selçuk Baysal
Nov 21, 2020·Progress in Retinal and Eye Research·Murray JohnstoneRuikang K Wang

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