Age corrections and dementia classification accuracy

Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists
M E O'Connell, H Tuokko

Abstract

In contrast to expectations, demographic corrections to reduce biases against those of advanced age or few years of education does not universally improve diagnostic classification accuracy. Age corrections may be particularly problematic because age is also a risk factor for a dementia diagnosis. We found that simulating increased risk for dementia based on demographic variables, such as age, reduced the overall classification accuracy for demographically corrected simulated scores relative to the raw, uncorrected test scores. In clinical data with a small magnitude of association between age and dementia diagnosis, we found equivalent overall classification accuracy for demographically corrected and raw test scores. Regardless of the overall classification accuracy results, cutoff comparisons (16th and 9th percentiles) in clinical and simulated data demonstrated that for the most part, the sensitivity of raw scores was higher than the sensitivity of demographically corrected scores, but the specificity of scores corrected with normative data was superior.

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Citations

Jul 6, 2010·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Michael CroweRoy C Martin
Feb 11, 2016·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·I ContadorJ Benito-León
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Francesca Di StefanoUNKNOWN GuidAge study group
Mar 1, 2015·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Ashita S GurnaniBrandon E Gavett
Sep 15, 2016·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Eddy LaroucheCarol Hudon
Sep 8, 2016·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Israel ContadorFélix Bermejo-Pareja
Nov 3, 2011·Nature Reviews. Neurology·Julie A FieldsGlenn E Smith
Dec 15, 2010·Journal of Clinical and Experimental Neuropsychology·Megan E O'ConnellHelena Kadlec
Oct 28, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Kristina ZawalyNgaire Kerse
Jun 28, 2018·Journal of Alzheimer's Disease : JAD·Alessandra E ThomannAndreas U Monsch

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