Age-correlated changes in cerebral hemodynamics assessed by near-infrared spectroscopy

Archives of Gerontology and Geriatrics
Larisa P SafonovaE Gratton

Abstract

Cerebral hemodynamic responses due to normal aging may interfere with hormonal changes, drug therapy, diseases, life style, and other factors. Age-correlated alterations in cerebral vasculature and autoregulatory mechanisms are the subject of interest in many studies. Near-infrared spectroscopy (NIRS) is widely used for monitoring cerebral hemodynamics and oxygenation changes at the level of small vessels. We believe that the compensatory ability of cerebral arterioles under hypoxic conditions and the dilatatory ability of cerebral vessels due to vasomotion may decline with normal aging. To test this hypothesis we used frequency-domain NIRS to measure changes in cerebral tissue oxygenation and oxy- and deoxy-hemoglobin concentrations caused by hypoxia during breath holding. We also assessed cerebral vasomotion during profound relaxation. Thirty seven healthy volunteers, 12 females and 25 males, ranging from 22 to 56 years of age (mean age 35 +/- 11 years) participated in the study. We observed age-correlated changes in the cerebral hemodynamics of normal subjects: diminished cerebral hemodynamic response to hypoxia due to breath holding in middle-aged subjects (38-56 years) and reduced amplitude of cerebral hemodynamic changes ...Continue Reading

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Citations

Jul 17, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·William LiboniChiara Benedetto
Aug 9, 2013·The British Journal of Nutrition·Stéphane V SizonenkoJohn W Sijben
Jan 19, 2010·Respiratory Research·Isaac AlmendrosRamon Farré
Oct 16, 2008·AJNR. American Journal of Neuroradiology·J M PollockJ A Maldjian
Jan 31, 2012·Brain and Language·Karima KahlaouiYves Joanette
May 15, 2013·NeuroImage·Monica FabianiGabriele Gratton
Oct 16, 2013·Pharmacology, Biochemistry, and Behavior·Jean-G GehrickeEnrico Gratton
Apr 30, 2014·Frontiers in Aging Neuroscience·Benjamin ZimmermanMonica Fabiani
Jan 31, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zengyong LiLiqian Lu
Jan 1, 2008·Journal of Biomedical Optics·Rodolfo GattoFady Charbel
Oct 14, 2010·Optics Express·Irina Schelkanova, Vladislav Toronov
Apr 23, 2021·Annals of Cardiac Anaesthesia·Lina Maria Ordóñez-Velasco, Edgar Hernández-Leiva

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