Age dependence of NMDA receptor involvement in epileptiform activity in rat hippocampal slices

Epilepsy Research
C Wang, F E Jensen

Abstract

The pattern of epileptiform activity recorded from a number of in vitro seizure models is age dependent: ictal discharges are observed in immature brain slices while interictal bursts are seen in adult brain slices. This study evaluated the involvement of the N-methyl-D-aspartate (NMDA) receptor in the age-dependency of epileptiform activity recorded in area CA1 of hippocampal slices in Mg(2+)-free medium. Incubation in Mg(2+)-free medium induced ictal activity in 84% of hippocampal slices from immature rats (postnatal 10-15 days). In contrast, adult slices responded with interictal bursting, while ictal activity was rare (9%). Bath application of the NMDA receptor antagonist D,L-2-amino-5-phosphonovaleric acid (DL-APV, 20 microM) converted ictal activity to interictal activity in the hippocampal slices from immature rats. In adult slices, bath application of NMDA (10-20 microM) in Mg(2+)-free medium induced ictal-like discharges. Perfusion with NMDA (20 microM) in a medium containing 1.5 mM Mg2+ induced ictal activity in immature slices while it evoked only interictal bursts in adult slices. These results suggest that differences in NMDA receptor function may be involved in the age-dependency of epileptiform activity induced b...Continue Reading

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Citations

Jun 19, 2007·Journal of Inherited Metabolic Disease·R Pessoa-Pureur, M Wajner
Oct 10, 2002·The European Journal of Neuroscience·P P QuilichiniH Gozlan
Jul 23, 2014·Oxidative Medicine and Cellular Longevity·Regina Pessoa-PureurJoão B Rocha
Aug 24, 2005·Seminars in Pediatric Neurology·Michael Wong
Jul 22, 2010·Seminars in Fetal & Neonatal Medicine·L BennetA J Gunn
Jul 26, 2017·Pain Practice : the Official Journal of World Institute of Pain·Sjoerd de HoogdCatherijne A J Knibbe
Jan 28, 2005·Journal of Neurophysiology·Claire WyartDidier Chatenay

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