PMID: 6088242Jun 1, 1984Paper

Age-dependency of alpha- and beta-adrenoceptors on thrombocytes and lymphocytes of asthmatic and nonasthmatic children

European Journal of Pediatrics
D ReinhardtM Nagel-Hiemke


Among the possible mechanisms which may cause wheezing or asthmatic episodes a genetically determined beta-adrenoceptor blockade and a hyperresponsiveness of alpha-adrenoceptors has been postulated. Evidence to support this hypothesis stems from an increased bronchial sensitivity to beta-blockers, a reduced formation of cyclic AMP in response to beta-adrenergic stimulation and enhanced alpha-adrenergic responses in asthmatic subjects. The recent development of techniques for measuring the specific, high-affinity binding of radiolabeled alpha- and beta-adrenergic antagonists made it possible to study alpha- and beta-adrenoceptors in vitro. Based upon the assumption that a change in the number and/or affinity of adrenergic receptors might be a general phenomenon, we have performed alpha- and beta-receptor binding studies on lymphocytes and platelets from wheezing infants and asthmatic children as well as of infants, children, and adults not suffering from these diseases. Using 125[I]-cyanopindolol (ICYP) and 3[H]-yohimbine (HYOH) as highly specific ligands for alpha- and beta-adrenoceptors, the following results were obtained: Lymphocytes and platelets from control subjects and asthmatics bound similar amounts of ICYP and HYOH an...Continue Reading


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Mar 22, 1979·The New England Journal of Medicine·W R HendersonM Kaliner
Aug 1, 1978·The Journal of Pediatrics·A F De SchaepdryverM V den Noortgaete
Jul 1, 1978·Archives of Disease in Childhood·W Lenney, A D Milner
Jan 1, 1976·The Journal of Clinical Investigation·L T WilliamsR J Lefkowitz
Mar 1, 1980·The Journal of Clinical Investigation·S P GalantP A Insel
Jan 1, 1980·The Journal of Allergy and Clinical Immunology·N H BishopricR J Lefkowitz
May 14, 1980·Biochemical and Biophysical Research Communications·C M Fraser, J C Venter
Jun 1, 1980·European Journal of Pediatrics·D ReinhardtF Wegner
Sep 1, 1981·Archives of Disease in Childhood·I G HodgesG M Stokes
Jul 1, 1980·European Journal of Clinical Pharmacology·A D Milner

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