PMID: 6088242Jun 1, 1984Paper

Age-dependency of alpha- and beta-adrenoceptors on thrombocytes and lymphocytes of asthmatic and nonasthmatic children

European Journal of Pediatrics
D ReinhardtM Nagel-Hiemke

Abstract

Among the possible mechanisms which may cause wheezing or asthmatic episodes a genetically determined beta-adrenoceptor blockade and a hyperresponsiveness of alpha-adrenoceptors has been postulated. Evidence to support this hypothesis stems from an increased bronchial sensitivity to beta-blockers, a reduced formation of cyclic AMP in response to beta-adrenergic stimulation and enhanced alpha-adrenergic responses in asthmatic subjects. The recent development of techniques for measuring the specific, high-affinity binding of radiolabeled alpha- and beta-adrenergic antagonists made it possible to study alpha- and beta-adrenoceptors in vitro. Based upon the assumption that a change in the number and/or affinity of adrenergic receptors might be a general phenomenon, we have performed alpha- and beta-receptor binding studies on lymphocytes and platelets from wheezing infants and asthmatic children as well as of infants, children, and adults not suffering from these diseases. Using 125[I]-cyanopindolol (ICYP) and 3[H]-yohimbine (HYOH) as highly specific ligands for alpha- and beta-adrenoceptors, the following results were obtained: Lymphocytes and platelets from control subjects and asthmatics bound similar amounts of ICYP and HYOH an...Continue Reading

References

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Citations

Feb 1, 1988·European Journal of Pediatrics·M KrauseK Kruse
Jan 1, 1989·European Journal of Pediatrics·D Reinhardt
Aug 17, 1989·Klinische Wochenschrift·A SchusterD Reinhardt
Dec 1, 1987·Psychiatry Research·G N PandeyJ M Davis
Jun 8, 2004·Pediatric Research·Brian W TimmonsOded Bar-Or
Oct 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P C PotterE B Dowdle
Jun 6, 2006·Allergologia et immunopathologia·R M Busquets MongeJ R Villa Asensi
May 5, 2006·Medicine and Science in Sports and Exercise·Brian W TimmonsOded Bar-Or
May 1, 1991·DICP : the Annals of Pharmacotherapy·D R Rutledge, J D Steinberg
Apr 1, 1988·European Journal of Clinical Investigation·M GrieseD Reinhardt
May 4, 2004·Allergologia et immunopathologia·R Ma Busquets MongeUNKNOWN Sociedad Española de Immunología Clínica y Alergia Pediátrica

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