Age dependency of renal function in CD-1 mice

American Journal of Physiology. Renal Physiology
Gerd LuippoldBernd Mühlbauer

Abstract

Renal function was studied in mice of different ages. In metabolic cage experiments, the renal electrolyte excretion was similar in young (n = 8; 5- to 7-wk-old) and adult (n = 6; 20- to 22-wk-old) CD-1 (ICR) BR mice, whereas spontaneous drinking volume and urinary flow rate were significantly higher in the adult compared with the young mice. Subsequently, the renal functional reserve was investigated by amino acid (AA) infusion (10%) in anesthetized young (n = 8) and adult (n = 6) mice. Because the body weight of adult mice was significantly higher than that of young animals, one group of adult mice (n = 8) received 12.5% AA to ensure that the dose of AA related to body weight was similar in both groups. Young animals constantly infused with Ringer solution served as time controls (n = 8). Glomerular filtration rate (GFR) at baseline was similar in each group. Because of AA, GFR significantly increased in young mice but not in both groups of adult animals, whereas in time controls GFR remained constant. Urinary flow rate and sodium excretion were elevated by AA in young and adult mice. We conclude that in CD-1 mice the first signs of age-related changes in kidney function concern alterations in renal hemodynamics, whereas rena...Continue Reading

References

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Citations

Dec 24, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Gerd LuippoldBernd Mühlbauer
May 12, 2009·Reproductive Toxicology·Chester E RodriguezHugh A Barton
Jun 19, 2016·Pflügers Archiv : European journal of physiology·Sergio Luis-LimaEsteban Porrini
Nov 14, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Inchio LouHugh A Barton
Nov 6, 2003·American Journal of Physiology. Renal Physiology·Zhonghua QiMatthew D Breyer

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