PMID: 15374461Jan 1, 1991Paper

Age dependency of the sialic acid content of fibrinogen. Consequences for erythrocyte aggregation

Archives of Gerontology and Geriatrics
K HagerD Platt

Abstract

Sialic acid (SA) content of plasma proteins and fibrinogen was investigated in 60 persons of different age and health status. SA/mg fibrin rose with age and morbidity in plasma, rinsed clots of fibrin from plasma and after prothrombin adsorption as well as in fibrin clots prepared from purified fibrinogen. The higher plasma SA is caused by increasing concentrations of glycoproteins like fibrinogen, but also by a higher content of SA/mg protein, as has been shown for fibrinogen. SA is considered to be an unspecific marker of acute phase reactions. Changing SA content of glycoproteins may have functional consequences. An increased red cell aggregation with fibrinogen of healthy elderly correlated with its SA content, but SA is most probably only indicating an altered protein heterogeneity in the aged and not a causative factor that influences erythrocyte aggregation.

References

Nov 1, 1977·Klinische Wochenschrift·G GrancińskaI Rawicz-Zegrzda
Nov 1, 1989·Archives of Gerontology and Geriatrics·K HagerD Platt
Jan 1, 1985·Journal of Cancer Research and Clinical Oncology·N StefenelliP Bauer
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Aug 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·L A KAZALL M TOCANTINS

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Citations

Jan 1, 1994·Archives of Gerontology and Geriatrics·K HagerD Platt
Aug 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·P J WatersR Eisenthal
Apr 21, 2006·Clinical Biochemistry·Karina P Gopaul, Martin A Crook

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