PMID: 9004199Dec 1, 1996Paper

Age-dependent alteration of the serum-unbound fraction of nicardipine, a calcium-channel blocker, in man

The Journal of Pharmacy and Pharmacology
N SugiokaK Nakajima

Abstract

To determine whether the age-dependent increase in the pharmacological effect of calcium-channel blockers is a result of age-dependent alteration of the unbound fraction the drug in serum, the unbound fraction of the nicardipine was investigated in the serum of 38 adults. The unbound concentration of nicardipine in serum to which nicardipine (205.4 ng mL-1) had been added was determined by ultracentrifugation to range from 0.49 to 4.01% (mean +/- s.d., 1.55 +/- 0.78%). Non-glycosylated albumin was most strongly correlated with age (r = 0.901). Total bilirubin was weakly correlated with age whereas levels of alpha-1-acid glycoprotein, triglycerides and glycosylated albumin were not correlated with age. A significant (P < 0.01) linear correlation was obtained between the unbound fraction of nicardipine and parameters such as age, albumin, albumin/globulin ratio, albumin/glycosylated albumin ratio, non-glycosylated albumin and total bilirubin. To assess the relative effect of each variable on the unbound fraction of nicardipine, stepwise multiple linear regression was performed using age and biochemical parameters. The three variables (non-glycosylated albumin, total bilirubin and age) were entered into the regression equation. Th...Continue Reading

References

Dec 1, 1978·British Journal of Clinical Pharmacology·A MonksA Richens
Apr 1, 1978·Archives of Internal Medicine·R H McDonaldJ Shuman
Jan 1, 1979·British Journal of Clinical Pharmacology·C M Castleden, C F George
Jul 1, 1991·British Journal of Clinical Pharmacology·J H AhmedH L Elliott
Oct 1, 1971·Circulation Research·B GribbinR Peto
Feb 13, 1967·JAMA : the Journal of the American Medical Association·R J CammarataR H Fennell
May 1, 1980·Clinical Pharmacokinetics·K M Piafsky
Jan 1, 1982·Journal of Cardiovascular Pharmacology·F R BühlerP Bolli
Sep 1, 1984·The Journal of Pediatrics·S F KempT R Horn
Nov 1, 1984·Clinical Pharmacology and Therapeutics·F Ruiz-Cabello, S Erill
Jan 1, 1984·European Journal of Clinical Pharmacology·R K VerbeeckS M Wallace
Apr 1, 1983·British Journal of Clinical Pharmacology·O BrørsS Jacobsen
Feb 1, 1981·Journal of Pharmaceutical Sciences·J B Whitlam, K F Brown
Dec 1, 1980·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S Higuchi, Y Shiobara
Dec 1, 1980·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S HiguchiT Seki
Jun 1, 1980·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S Higuchi, Y Shiobara
Jan 1, 1993·Fundamental & Clinical Pharmacology·M D DriciP Lapalus

❮ Previous
Next ❯

Citations

Mar 31, 2012·Future Medicinal Chemistry·A WickendenG Erdemli
Nov 15, 2008·Biopharmaceutics & Drug Disposition·Nobuyuki SugiokaKanji Takada

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Pharmacy and Pharmacology
L PatelP Turner
Journal of Molecular and Cellular Cardiology
Manhal HabibLior Gepstein
Assay and Drug Development Technologies
Larisa StankovichDong Liang
© 2022 Meta ULC. All rights reserved