Age-dependent alterations in CRMP2 and CRMP4 protein expression profiles in cat visual cortex

Brain Research
Lieselotte CnopsLutgarde Arckens

Abstract

We monitored the protein expression profiles of collapsin response mediator protein 2 and 4 (CRMP2 and CRMP4) throughout cat primary visual area 17 at different postnatal ages. Single immunocytochemical stainings revealed a clear effect of cortical maturation on the spatial and laminar distribution profile of CRMP2 and CRMP4. In kittens of postnatal day 10 (P10) and 30 (P30), CRMP2 and CRMP4 immunoreactivity was exclusively present in fibers running perpendicular to the cortical surface and crossing all cortical layers, but was never found in neuronal cell bodies. The immunoreactive fibers were embedded in an intensely and homogeneously stained neuropil. In contrast, mature visual cortex immunocytochemistry located CRMP2 and CRMP4 in the somatodendritic compartment of neurons with a clear CRMP-specific lamination pattern. Similar to kitten, neuropil staining was clearly observed but showed a decreasing gradient from layer I to VI in adult area 17. Detailed analysis of cellular morphology and size classified the CRMP2- and CRMP4-immunopositive cells in distinct neuronal populations. Double labeling of CRMP2 or CRMP4 with the typical interneuron marker parvalbumin (PV) showed many double-labeled cells immunoreactive for CRMP4 and...Continue Reading

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Citations

Apr 9, 2016·Neural Plasticity·F de WinterJ Verhaagen
Oct 4, 2011·Aquatic Toxicology·Adam D BialesDavid L Lattier
Apr 12, 2007·The European Journal of Neuroscience·Lieselotte CnopsLutgarde Arckens
Jul 24, 2012·Journal of Anatomy·Atsuhiro Tsutiya, Ritsuko Ohtani-Kaneko
Jun 30, 2015·The European Journal of Neuroscience·Atsuhiro TsutiyaRitsuko Ohtani-Kaneko
Nov 18, 2011·Neurobiology of Aging·Neal D Mehan, Kenneth I Strauss
Jan 1, 2013·Journal of Experimental Neuroscience·Annelies LaeremansTjing-Tjing Hu
Mar 28, 2019·Molecular Neurobiology·Aubin MoutalRajesh Khanna
May 30, 2019·International Journal of Molecular Sciences·Ritsuko Ohtani-Kaneko
May 29, 2021·Frontiers in Synaptic Neuroscience·Daniela CarulliJoost Verhaagen

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