Age-dependent alterations in the cortical entrainment of subthalamic nucleus neurons in the YAC128 mouse model of Huntington's disease

Neurobiology of Disease
Joshua W Callahan, Elizabeth D Abercrombie

Abstract

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that results in motor, cognitive and psychiatric abnormalities. Dysfunction in neuronal processing between the cortex and the basal ganglia is fundamental to the onset and progression of the HD phenotype. The corticosubthalamic hyperdirect pathway plays a crucial role in motor selection and blockade of neuronal activity in the subthalamic nucleus (STN) results in hyperkinetic movement abnormalities, similar to the motor symptoms associated with HD. The aim of the present study was to examine whether changes in the fidelity of information transmission between the cortex and the STN emerge as a function of phenotypic severity in the YAC128 mouse model of HD. We obtained in vivo extracellular recordings in the STN and concomitant electrocorticogram (ECoG) recordings during discrete brain states that reflected global cortical network synchronization or desynchronization. At early ages in YAC128 mice, both the cortex and the STN exhibited patterns of hyperexcitability. As symptom severity progressed, cortical entrainment of STN activity was disrupted and there was an increase in the proportion of non-oscillating, tonically firing STN neurons that were less...Continue Reading

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Citations

Mar 24, 2016·Brain Structure & Function·Luc DriencourtNathalie Just
Sep 2, 2020·The Journal of Comparative Neurology·Yunping DengAnton Reiner
Mar 3, 2020·Frontiers in Neuroscience·Sonja Blumenstock, Irina Dudanova
Apr 15, 2017·Frontiers in Computational Neuroscience·Taegyo KimYaroslav I Molkov
Nov 18, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Carlos Cepeda, Michael S Levine

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