Age-dependent alterations in the inflammatory response to pulmonary challenge

Immunologic Research
Helena M LingeEdmund J Miller

Abstract

The aging lung is increasingly susceptible to infectious disease. Changes in pulmonary physiology and function are common in older populations, and in those older than 60 years, pneumonia is the major cause of infectious death. Understanding age-related changes in the innate and adaptive immune systems, and how they affect both pulmonary and systemic responses to pulmonary challenge are critical to the development of novel therapeutic strategies for the treatment of the elderly patient. In this observational study, we examined age-associated differences in inflammatory responses to pulmonary challenge with cell wall components from Gram-positive bacteria. Thus, male Sprague-Dawley rats, aged 6 months or greater than 18 months (approximating humans of 20 and 55-65 years), were challenged, intratracheally, with lipoteichoic acid and peptidoglycan. Cellular and cytokine evaluations were performed on both bronchoalveolar lavage fluid (BAL) and plasma, 24 h post-challenge. The plasma concentration of free thyroxine, a marker of severity in non-thyroidal illness, was also evaluated. The older animals had an increased chemotactic gradient in favor of the airspaces, which was associated with a greater accumulation of neutrophils and pr...Continue Reading

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Citations

Oct 16, 2016·Cell and Tissue Research·Christina Brandenberger, Christian Mühlfeld
Jun 21, 2017·International Journal of Molecular Sciences·Edmund J Miller, Helena M Linge
Sep 3, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tolga YaziciogluChristina Brandenberger
Nov 2, 2016·Expert Opinion on Therapeutic Targets·Joshua BloomYousef Al-Abed
Oct 1, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kevin W GibbsD Clark Files

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Methods Mentioned

BETA
bronchoalveolar
lavage
Bronchoalveolar Lavage
enzyme-linked immunosorbent assay

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