Age-dependent aluminum accumulation in the human aorta and cerebral artery

Biological Trace Element Research
T MinamiY Okazaki

Abstract

The purpose of this study was to determine the extent of aluminum (Al) accumulation in the human aorta and cerebral arteries. The Al contents in the aortae and in the cerebral arteries from 23 human subjects was determined by inductively coupled plasma atomic emission spectrophotometry (ICP-AES). The subjects' age range was 45-99-yr-old; 15 of the subjects were males and 8 were females. Al was detected in twelve aortae and in six cerebral arteries, when the entire specimen was analyzed. Two specimens where Al was found in the cerebral arteries contained no Al in the aorta. No relationship to the subject's sex was found. When related to age, two groups were established. Group L (45-75 yr old) and group H (> 75 yr old), which exhibited aortal Al concentrations of 33.3 and 72.7%, respectively. When the aortic wall was dissected into the tunica intima, media, and adventitia, Al was found mainly in the tunica media. In the aorta, significant relationships were found between Al and phosphorus (P) levels (r = 0.801, p < 0.01) and between Al and calcium (Ca) (r = 0.661, p < 0.05). We have concluded that Al accumulation is age-dependent and that it occurs both in the aorta and in the cerebral artery. In the aorta, accumulation occurs ma...Continue Reading

References

Apr 29, 1978·British Medical Journal·H L ElliottA I Macdougall
May 1, 1992·Annals of Clinical Biochemistry·W S YunR Swaminathan
Mar 1, 1992·Pharmacology & Toxicology·G B van der VoetF A de Wolff
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A J Roskams, J R Connor
Jan 15, 1987·Nature·K Tennakone, S Wickramanayake
Jul 1, 1980·The American Journal of Clinical Nutrition·A C AlfreyP Craswell
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·G D Fasman, C D Moore
Apr 1, 1994·Calcified Tissue International·R J Elliott, L T McGrath
Dec 1, 1993·Therapeutic Drug Monitoring·R T ErasmusM M Herman
Dec 1, 1993·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·A H el-SebaeM A Saleh

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Citations

Jan 1, 1997·Biological Trace Element Research·S TohnoM Yamada
Sep 1, 1997·Toxicology and Industrial Health·D E Abercrombie, R C Fowler
Apr 14, 1999·Biological Trace Element Research·Y TakanoK Yamamoto

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